Hepatic Disorders Associated with Liver/Kidney Microsomal Antibodies
Hepatic Disorders Associated with Liver/Kidney Microsomal Antibodies
复制标题
与肝/肾微粒体抗体相关的肝脏疾病
作者：
M. Smith;R. Williams;G. Walker;M. Rizzetto;D. Doniach
一项最近定义的组织自身抗体（肝/肾微粒体 (L.K.M.) 抗体）的临床关联研究表明，33 名患者中有 26 名患有临床肝病。其中 15 名患者患有活动性慢性肝炎，7 例患有急性肝炎，其中 3 例疑似由甲型病毒感染引起，另外 4 例由药物过敏引起。其余肝病病例包括两例亚临床肝炎和两例肝细胞癌。有证据表明，活动性慢性肝炎患者可能代表该疾病的一个独特亚组，其平均年龄年轻，男女比例均匀，并且明显缺乏其他非器官特异性自身抗体（即抗核抗体和平滑肌抗体），而这些抗体通常存在于该疾病的其他自身免疫变异中。
A study of the clinical associations of a recently defined tissue autoantibody, the liver/kidney microsomal (L.K.M.) antibody, showed that out of 33 patients 26 had clinical liver disease. Fifteen of the patients had active chronic hepatitis and there were seven cases of acute hepatitis, precipitated by presumed virus A infection in three instances and by drug hypersensitivity in the other four. The remaining cases with liver disease included two with subclinical hepatitis and two with hepatocellular carcinoma. Evidence is presented that the patients with active chronic hepatitis may represent a distinct subgroup of the disease with a young mean age, an even male to female ratio, and a striking lack of other nonorgan-specific autoantibodies—that is, antinuclear and smooth muscle—which are usually present in the other autoimmune variant of the disease.