Clinical significance of circulating immune complexes in patients with metastatic breast cancer
Clinical significance of circulating immune complexes in patients with metastatic breast cancer
复制标题
转移性乳腺癌患者循环免疫复合物的临床意义
DOI：
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发表时间：
1983
影响因子：
6.4
通讯作者：
EL G.A.NAG
中科院分区：
文献类型：
--
作者：
G. Krieger;A. Kehl;H. Wander;A. Salo;H. and;EL G.A.NAG
用氯离子结合试验（Cba）和Raji细胞试验（Rca）对158例转移性乳腺癌（mbc）患者血清循环免疫复合物（CIC）进行了重复测定。与年龄匹配的健康女性相比，mbc中CIC的发生频率和水平仅略有增加。它们与乳房切除术前局部乳腺癌患者和乳房切除术后无复发疾病证据的患者相同。在mbc的CBA和RCA的结果显示出较差的相关性，而在类风湿性关节炎患者的对照组中，两种测试均显示出CIC水平显着升高。通过连续测量CIC对mbc患者进行临床和生化随访，平均随访10个月。CIC阳性的患者在疾病进展和化疗反应方面并不是一个不利的群体。当比较CEA和CIC水平时，与CEA不同，CIC是一种较差的肿瘤标志物。总之，通过Cl结合试验和Raji细胞试验测量的CIC不是转移性乳腺癌患者的临床显著肿瘤标志物或预后指标。
Serum circulating immune complexes (CIC) were repeatedly measured by means of the Cl binding assay (Cba) and the Raji cell assay (Rca) in 158 patients with metastatic breast cancer (mbc). Frequency of occurrence and levels of CIC were only slightly increased in mbc when compared to age‐matched healthy women. They were identical to those of patients with localized breast cancer prior to mastectomy and to those of post mastectomy patients without evidence of recurrent disease. In mbc the results of the Cba and the Rca showed a poor correlation, whereas in a control group of patients with rheumatoid arthritis both tests showed significantly elevated levels of CIC. Patients with mbc were followed up clinically and biochemically by serially measuring CIC for an average of 10 months. Patients with positive CIC did not prove to be an unfavorable group regarding progression of disease and response to chemotherapy. When CEA and CIC levels were compared, CIC, unlike CEA, was a poor tumor marker. In conclusion, CIC as measured by Cl binding assay and Raji cell assay are not clinically significant tumor markers or prognostic indicators in patients with metastatic breast cancer.
通过制备型等电聚焦从乳腺癌免疫复合物中回收免疫反应性抗体和抗原。
影响因子：
11.2
作者：
MaidmentJr,BW;Papsidero,LD;Nemoto,T;Chu,TM
通讯作者：
Chu,TM
通过抗人乳腺癌 Raji 细胞结合循环免疫复合物的抗血清检测乳腺组织相关抗原。
影响因子：
11.2
作者：
Koestler,TP;Papsidero,LD;Nemoto,T;Chu,TM
通讯作者：
Chu,TM