Beneficial effects of dietary capsaicin in gastrointestinal health and disease.
Beneficial effects of dietary capsaicin in gastrointestinal health and disease.
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DOI：
10.1016/j.yexcr.2022.113227
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发表时间：
2022-05
影响因子：
3.7
通讯作者：
Yiwei Xiang;Xiaolin Xu;Ting Zhang;Xianli Wu;Dongdong Fan;Yanxia Hu;Jianhong Ding;Xiaoxu Yang;Jun Lou;Qian Du;Jingyu Xu;R. Xie
中科院分区：
文献类型：
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作者：
Yiwei Xiang;Xiaolin Xu;Ting Zhang;Xianli Wu;Dongdong Fan;Yanxia Hu;Jianhong Ding;Xiaoxu Yang;Jun Lou;Qian Du;Jingyu Xu;R. Xie
辣椒及其主要活性化合物辣椒素长期以来不仅被用作日常食品添加剂，而且在全世界范围内被用作药物。与其他人体器官和系统一样，辣椒素在胃肠 (GI) 生理和病理学中具有多种作用。大量研究表明，辣椒素以 TRPV1 依赖性和非依赖性方式作用于胃肠道，主要取决于其摄入浓度。在这篇综述中，我们将重点关注辣椒素在胃肠道中的有益作用，这是一个不太突出的方面，特别是膳食辣椒素如何影响胃肠道健康、作用机制及其对几种胃肠道疾病的预防/治疗潜力。膳食辣椒素不仅通过 TRPV1 依赖和独立的方式影响胃肠道，而且还通过急性和慢性作用。虽然膳食中高剂量摄入辣椒素有时对人体健康有害，但目前的文献表明，适当剂量的摄入可能有益于胃肠道健康，并且在大多数情况下对胃肠道疾病也具有预防/治疗作用。通过对其胃肠道作用进行广泛深入的研究，辣椒素作为日常食用的食品添加剂，有可能成为治疗多种胃肠道疾病的安全药物。
Chili pepper and its major active compound capsaicin have long been used not only a daily food additive but also medication worldwide. Like in other human organs and systems, capsaicin has multiple actions in gastrointestinal (GI) physiology and pathology. Numerous studies have revealed that capsaicin acts on GI tract in TRPV1-dependent and –independent manners, mostly depending on its consumption concentrations. In this review, we will focus on the beneficial role of capsaicin in GI tract, a less highlighted aspect, in particular how dietary capsaicin affects GI health, the mechanisms of actions and its preventive/therapeutic potentials to several GI diseases. Dietary capsaicin affects GI tract not only via TRPV1-derpendent and independent manners, but also via acute and chronic effects. Although high dose intake of dietary capsaicin is harmful to human health sometimes, current literatures suggest that appropriate dose intake is likely beneficial to GI health and is preventive/therapeutic to GI disease in most cases as well. With extensive and intensive studies on its GI actions, capsaicin, as a daily consumed food additive, has potential to become a safe drug for the treatment of several GI diseases.