Physiology and pathophysiology of the interstitial cell of Cajal: From bench to bedside - II. Gastric motility: lessons from mutant mice on slow waves and innervation
Physiology and pathophysiology of the interstitial cell of Cajal: From bench to bedside - II. Gastric motility: lessons from mutant mice on slow waves and innervation
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DOI：
10.1152/ajpgi.2001.281.5.g1129
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发表时间：
2001-11-01
影响因子：
4.5
通讯作者：
Huizinga, JD
中科院分区：
文献类型：
--
作者：
Huizinga, JD
胃内有与奥尔巴赫神经丛相关的Cajal间质细胞(ICC)网络，以及与神经静脉曲张密切接触的肌层内的ICC。ICC对慢波的产生至关重要，使ICC成为肠道的起搏细胞，允许中胃和远端胃有节奏的蠕动模式。ICC也在神经传递中发挥作用，但其相对于直接肌肉神经支配的重要性仍在研究中。ICC在人体许多胃运动控制功能中的作用有待进一步研究。免疫组织化学和电子显微镜可部分评价ICC在疾病中的病理生理学作用。胃电测量也可能起到一定作用，但这项技术还需要进一步完善。ICC和肌肉之间的通信可能涉及电耦合、通过缝隙连接的代谢耦合或一氧化氮或一氧化碳的分泌。
The stomach harbors a network of interstitial cells of Cajal (ICC) associated with Auerbach's plexus as well as intramuscular ICC within the muscle layers that make close apposition contact with nerve varicosities. ICC are critical for slow-wave generation, making ICC the pacemaker cells of the gut, allowing rhythmic peristaltic motor patterns in the mid- and distal stomach. ICC also play a role in neurotransmission, but its importance relative to direct muscle innervation is still under investigation. The role of ICC in many control functions of gastric motility in humans needs further examination. The pathophysiology of ICC in disease can be partially assessed by immunohistochemistry and electron microscopy on tissue samples. Electrogastrogram measurements may also play a role, but this technique needs further refinement. Communication between ICC and muscle may involve electrical coupling, metabolic coupling through gap junctions, or secretion of nitric oxide or carbon monoxide.