Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: results from the National Epiderniologic Survey on Alcohol and Related Conditions
Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: results from the National Epiderniologic Survey on Alcohol and Related Conditions
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DOI：
10.1017/s0033291705006069
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发表时间：
2005-12-01
影响因子：
6.9
通讯作者：
Huang, BJ
中科院分区：
文献类型：
--
作者：
Grant, BF;Hasin, DS;Huang, BJ
背景资料。这项研究探讨了DSM-IV广泛性焦虑症(GAD)和其他精神障碍的患病率、相关性、共同发病率和残疾，这是一项针对普通人群的大型全国性调查，国家酒精滥用和酒精中毒研究所(NIAAA)的全国酒精及相关疾病流行病学调查(NESARC)。这项研究首次提出了具有全国代表性的数据，关于DSM-IV GAD的患病率、相关性、共同发病率和相对残疾。数据取自具有代表性的大样本(n=43093)的美国成年人。12个月和终生GAD的患病率分别为2(.)1%和4(.)1%。女性、中年、丧偶/分居/离婚和低收入会增加风险，而亚裔、西班牙裔或黑人则会降低风险。GAD与药物使用以及其他焦虑、情绪和人格障碍高度并存。广泛性焦虑症的共同发病率并不比大多数其他轴心I和II疾病高。单纯GAD的残疾和损害等同于纯粹的情绪障碍，但明显高于纯粹的物质使用以及其他焦虑和人格障碍。GAD和每种情绪障碍的共病个体比那些单纯形式的GAD或每种情绪障碍的个体更残疾。当与GAD共病时，尼古丁依赖和其他焦虑和人格障碍与与单纯GAD相关的残疾增加并不相关，但GAD确实显示出与这些疾病中的每一种纯粹形式相关的残疾增加。GAD与轴I和轴II障碍之间的关联强烈而显著，不同的疾病之间存在差异。结果有力地支持广泛性AD是一种具有显著损害和残疾的独立障碍。
Background. This study addressed the prevalences, correlates, co-morbidity and disability of DSM-IV generalized anxiety disorder (GAD) and other psychiatric disorders in a large national survey of the general population, the National Institute on Alcohol Abuse and Alcoholism's (NIAAA) National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). The study presents nationally representative data, for the first time, on prevalence, correlates, co-morbidity, and comparative disability of DSM-IV GAD.Method. Data are taken from a large (n = 43093) representative sample of the adult USA population.Results. Prevalences of 12-month and lifetime GAD were 2(.)1% and 4(.)1%. Being female, middle-aged, widowed/separated/divorced, and low income increased risk, while being Asian, Hispanic, or Black decreased risk. GAD was highly co-morbid with substance use, and other anxiety, mood, and personality disorders. Co-morbidity in GAD was not substantially greater than for most other Axis I and II disorders. Disability and impairment in pure GAD were equivalent to pure mood disorders, but significantly greater than in pure substance use, and other anxiety and personality disorders. Individuals co-morbid for GAD and each mood disorder were more disabled than those with pure forms of GAD or each mood disorder. When co-morbid with GAD, nicotine dependence and other anxiety and personality disorders were not associated with increased disability over that associated with pure GAD, but GAD did show increased disability over that due to each of these disorders in pure form.Conclusions. Associations between GAD and Axis I and II disorders were strong and significant, with variation among specific disorders. Results strongly support GAD as an independent disorder with significant impairment and disability.