Preprogramming and control activity of bimanual self-paced motor task in Parkinson's disease
Preprogramming and control activity of bimanual self-paced motor task in Parkinson's disease
复制标题
帕金森病双手自定进度运动任务的预编程和控制活动
DOI：
10.1016/s1388-2457(00)00255-8
复制
发表时间：
2000
影响因子：
4.7
通讯作者：
G. Amabile
中科院分区：
文献类型：
--
作者：
F. Fattapposta;F. Pierelli;G. Traversa;F. My;M. Mostarda;C. D'alessio;G. Soldati;J. Osborn;G. Amabile
作者研究了编程（Bereitschaftspotential或BP）和对照活性（熟练的性能积极性或SPP）的双手，顺序，熟练的运动行为在关闭治疗帕金森病（PD）patients.MethodsWe记录运动相关电位（MRP）在12个，非痴呆，关闭治疗帕金森病患者和17个对照组谁是执行一个熟练的，时间锁定的运动行为，这在他们的日常生活中不是常规的，但必须学习：技能表现任务（SPT）。BP，SPP和正确的性能进行了评估，在总平均波形和顺序block.ResultsThe正确的性能分析表明，在PD患者的准确性显着低于对照组，这种准确性并没有提高整个块。PD患者BP波幅升高（P <0.05），SPP波幅降低（P <0.05），运动技能水平显著降低（P <0.05）。我们讨论的观点，PD患者可能会分配更多的注意力资源，建议增加BP幅度，降低SPP幅度和低正确的性能，以执行一个新的熟练的运动行为。
ObjectiveThe authors investigated programming (Bereitschaftspotential or BP) and control activity (Skilled Performance Positivity or SPP) of a bimanual, sequential, skilled motor act in off-therapy Parkinson's disease (PD) patients.MethodsWe recorded Movement Related Potentials (MRPs) in 12, non-demented, off-therapy parkinsonian patients and in 17 control subjects who were performing a skilled, time-locked motor act, which was not routine in their everyday life but had to be learned: the Skilled Performance Task (SPT). BP, SPP and correct performances were evaluated in grand average waveforms and in sequential blocks.ResultsThe analysis of correct performances showed that accuracy in PD patients was significantly lower than in the control group and this accuracy did not improve throughout the blocks. A significantly low level of performances was associated with an increased BP amplitude (P<0.05) and decreased SPP amplitude (P<0.05) in PD patients.ConclusionOur findings suggest that skill motor learning is impaired in non-demented unmedicated PD patients. We discuss the view that PD patients may allocate more attentional resources, as suggested by the increased BP amplitude, the decreased SPP amplitude and the low correct performances, in order to perform a new skilled motor act.