Axl and immune checkpoints inhibitors from fruiting bodies of Pleurocybella porrigens
Axl and immune checkpoints inhibitors from fruiting bodies of Pleurocybella porrigens
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DOI：
10.1038/s41429-020-0323-4
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发表时间：
2020-05
期刊：
影响因子：
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通讯作者：
A. Ridwan;Jing Wu;Etsuko Harada;Corina N. D´Alessandro-Gabazza;M. Toda;T. Yasuma;E. Gabazza;
中科院分区：
文献类型：
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作者：
A. Ridwan;Jing Wu;Etsuko Harada;Corina N. D´Alessandro-Gabazza;M. Toda;T. Yasuma;E. Gabazza;
从 Pleurocybella porrigens 的子实体中分离出一种新化合物 (1) 和三种已知化合物 (2−4)。该新型化合物的结构通过一维和二维核磁共振以及 HRESIMS 数据确定。使用A549肺癌细胞系评估1−3的生物活性。结果显示化合物1~3对Axl和免疫检查点分子的表达具有抑制活性。
A novel compound (1) and three known ones (2−4) were isolated from the fruiting bodies ofPleurocybella porrigens. The structure of the novel compound was determined by 1D and 2D NMR and HRESIMS data. The biological activity of1−3was evaluated using the A549 lung cancer cell line. The results showed the inhibitory activity of compounds1−3on the expression of Axl and immune checkpoint molecules.