Conserved role of nanos proteins in germ cell development
Conserved role of nanos proteins in germ cell development
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DOI：
10.1126/science.1085222
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发表时间：
2003-08-29
期刊：
影响因子：
56.9
通讯作者：
Saga, Y
中科院分区：
文献类型：
--
作者：
Tsuda, M;Sasaoka, Y;Saga, Y
在果蝇中，母体提供的 Nanos 在原始生殖细胞 (PGC) 迁移到性腺的过程中发挥作用。在小鼠中，则涉及合子基因。我们报告了 nanos2 和 nanos3 在小鼠体内的克隆和功能分析。这些基因在小鼠 PGC 中差异表达。 nanos2 主要在雄性生殖细胞中表达，消除该基因会导致精原细胞完全丧失。然而，nanos3 存在于迁移的 PGC 中，消除该因子会导致两性生殖细胞完全丧失。因此，尽管小鼠和果蝇的生殖细胞特化机制不同，但无脊椎动物和脊椎动物中的纳米蛋白似乎具有保守的功能。
In Drosophila, maternally supplied Nanos functions in the migration of primordial germ cells (PGCs) into the gonad; in mice, zygotic genes are involved instead. We report the cloning and the functional analyses of nanos2 and nanos3 in mice. These genes are differentially expressed in mouse PGCs. nanos2 is predominantly expressed in male germ cells, and the elimination of this gene results in a complete loss of spermatogonia. However, nanos3 is found in migrating PGCs, and the elimination of this factor results in the complete loss of germ cells in both sexes. Hence, although mice and flies differ in their mechanisms for germ cell specification, there seems to be conserved function for nanos proteins among invertebrates and vertebrates.