Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway
Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway
复制标题
佛手柑烯通过调节 ANP32A/ATM 信号通路缓解骨关节炎
DOI：
10.1002/2211-5463.12648
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发表时间：
2019-06-01
期刊：
影响因子：
2.6
通讯作者：
Zhao, Jinmin
中科院分区：
文献类型：
--
作者：
He, Yi;Zeng Zisan;Zhao, Jinmin
骨关节炎（OA）是一种常见于老年人的慢性退行性疾病。目前用于治疗OA的药物疗法可能引起不良副作用，因此仍然需要开发替代治疗。Bergapten（BG）是一种香豆素植物激素，广泛存在于水果中，具有抗氧化和抗炎作用。在这里，我们测试的假设，BG可能会限制OA的进展，通过检查其对OA软骨细胞的影响。我们观察到BG显著改善白细胞介素（IL）-1 β诱导的炎症细胞因子和介质的表达，包括白细胞介素1（IL-1）、白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）、环氧合酶2（考克斯-2）和基质金属蛋白酶13（Mmp-13），维持软骨细胞表型，并促进软骨特异性细胞外基质的分泌。我们提供的证据表明，BG通过激活ANP 32A/ATM信号通路发挥其抗炎作用，最近证实与OA相关。总之，这些发现表明BG可能是治疗OA的潜在候选药物。
Osteoarthritis (OA) is a chronic degenerative disease that commonly affects the elderly. Current drug therapies for treating OA may cause adverse side effects, and so there remains a need to develop alternative treatments. Bergapten (BG) is a coumarin phytohormone that is widely found in fruits and has antioxidative and anti‐inflammatory effects. Here, we tested the hypothesis that BG may restrict the progression of OA by examining its effect on OA chondrocytes. We observed that BG significantly ameliorated interleukin (IL)‐1β‐induced expression of inflammatory cytokines and mediators, including interleukin 1 (Il‐1), interleukin 6 (Il‐6), tumor necrosis factor α (Tnf‐α), cyclooxygenase 2 (Cox‐2) and matrix metalloproteinase 13 (Mmp‐13), maintained chondrocyte phenotype, and promoted the secretion of cartilage‐specific extracellular matrix. We provide evidence that BG exerts its anti‐inflammatory effect by activating the ANP32A/ATM signaling pathway, which was recently verified to be associated with OA. In conclusion, these findings indicate that BG may be a potential candidate for treatment of OA.