Radiologic-pathological correlation of punctate hyperechoic foci by ultrasound in stereotactic vacuum-assisted breast biopsy samples
Radiologic-pathological correlation of punctate hyperechoic foci by ultrasound in stereotactic vacuum-assisted breast biopsy samples
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DOI：
10.1007/s11604-009-0367-7
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发表时间：
2009-12-01
影响因子：
2.1
通讯作者：
Nakajima, Yasuo
中科院分区：
文献类型：
--
作者：
Okazaki, Hiroko;Tsujimoto, Fumio;Nakajima, Yasuo
为了将超声（US）上的点状强回声灶（PHF）与乳腺X线摄影（MMG）和组织病理学检测到的微钙化相关联，对2008年4月至12月期间接受立体定向真空辅助乳腺活检（SVABB）以评估乳腺微钙化的48例受试者进行了191处SVABB后获得的病变的评估。因此，评价了191处病变的超声PHF与MMG检测到的微钙化和组织病理学之间的一致性。以组织病理学为参考标准，确定敏感性和特异性值，在191例样本中，154例（80.6%）超声上的PHF与MMG和组织病理学上的微钙化相对应。超声诊断的敏感性和特异性分别为85.3%和80.0%，MMG诊断的敏感性和特异性分别为89.7%和90.7%。US和MMG值之间无显著差异。在US，12例PHF与MMG或组织病理学检查的任何微钙化无关。组织学检查发现5例脂肪组织中有胶原纤维，2例胶原化，超声检查显示PHF与MMG检查发现的微钙化基本一致。然而，除了微钙化外，脂肪组织中的胶原纤维和胶原化也可能导致部分PHF。在解释美国调查结果时应考虑这种可能性。
To correlate punctate hyperechoic foci (PHF) on ultrasound (US) with microcalcifications detected by mammography (MMG) and at histopathology.Forty-eight subjects who underwent stereotactic vacuum-assisted breast biopsy (SVABB) for evaluation of breast microcalcifications between April and December 2008 were evaluated for 191 lesions obtained after SVABB. The concordance between PHF on US with microcalcifications detected on MMG and histopathology was therefore evaluated for 191 lesions. Values for sensitivity and specificity were determined against histopathology as the reference standard.In 154 of 191 samples (80.6%), the PHF on US corresponded with microcalcifications on MMG and histopathology. The overall sensitivity and specificity were 85.3% and 80.0%, respectively, for US, and 89.7% and 90.7%, respectively, for MMG. There were no significant differences between values for US and MMG. At US, 12 PHF did not correlate with any microcalcifications at MMG or histopathology. Histopathology revealed collagen fibers in fatty tissue in 5 of 12 lesions and collagenization in 2 of 12 lesions.There was a general concordance between PHF on US and microcalcifications detected at MMG. However, in addition to microcalcifications, collagen fibers in fatty tissue and collagenization may account for some PHF. This possibility should be considered when interpreting US findings.