Integrating sequence and structural biology with DAS
Integrating sequence and structural biology with DAS
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DOI：
10.1186/1471-2105-8-333
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发表时间：
2007-09-12
影响因子：
3
通讯作者：
Hubbard, Tim J. P.
中科院分区：
文献类型：
--
作者：
Prlic, Andreas;Down, Thomas A.;Hubbard, Tim J. P.
背景：分布式注释系统（DAS）是一种用于交换生物数据的网络协议。它经常被用于共享基因组和蛋白质序列的注释。结果：这里我们给出了当前DAS 1.5协议的几个扩展。它们提供了共享排列、三维分子结构数据的新命令，增加了注册和发现DAS服务器的可能性，并提供了如何提供不同类型数据图的约定。我们给出了使用新扩展的网站和应用程序的示例。我们操作一个DAS源的公共注册表，它现在包含250多个不同源的条目。结论：我们的DAS扩展对于管理越来越多的服务和交换不同的生物数据集是必不可少的。此外，扩展允许开发新型应用程序和解决科学问题。可以在http://www.dasregistry.org上找到DAS源的注册表。
Background: The Distributed Annotation System (DAS) is a network protocol for exchanging biological data. It is frequently used to share annotations of genomes and protein sequence.Results: Here we present several extensions to the current DAS 1.5 protocol. These provide new commands to share alignments, three dimensional molecular structure data, add the possibility for registration and discovery of DAS servers, and provide a convention how to provide different types of data plots. We present examples of web sites and applications that use the new extensions. We operate a public registry of DAS sources, which now includes entries for more than 250 distinct sources.Conclusion: Our DAS extensions are essential for the management of the growing number of services and exchange of diverse biological data sets. In addition the extensions allow new types of applications to be developed and scientific questions to be addressed. The registry of DAS sources is available at http://www.dasregistry.org.