Decreased response inhibition in middle-aged male patients with type 2 diabetes.
Decreased response inhibition in middle-aged male patients with type 2 diabetes.
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DOI：
10.1186/1751-0759-4-1
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发表时间：
2010-02-11
影响因子：
2.1
通讯作者：
Iwamoto Y
中科院分区：
文献类型：
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作者：
Ishizawa KT;Kumano H;Sato A;Sakura H;Iwamoto Y
本研究旨在检查2型糖尿病患者是否存在与前额叶皮层（PFC）相关的认知缺陷。对27例新诊断的2型糖尿病中年患者和27例健康对照者进行了身体测量和神经心理任务。通过Go/NoGo任务、逆转和消退任务以及威斯康星州卡片分类测试（WCST）评估反应抑制、奖励预测和执行功能。为了研究超重与糖尿病对认知表现的相互作用，通过双因素ANCOVA分析了表现数据，其中糖尿病和超重作为因素，年龄作为协变量。2型糖尿病患者在Go/NoGo任务中表现出显著降低的反应抑制（辨别指数：P = 0.001）。在Go/NoGo任务的Go试验中，超重与糖尿病对反应时间有相互作用（P = 0.009）。在灭绝任务中，超重与对奖励预感的保留反应有关（P = 0.029）。四组在WCST中表现出正常的认知表现。我们的研究结果表明，中年，新诊断和无药物治疗的2型糖尿病患者有一个特殊的神经心理缺陷，抑制控制的冲动反应，这是一个独立的影响，糖尿病除了超重。
This study was performed to examine whether patients with type 2 diabetes have cognitive deficits associated with the prefrontal cortex (PFC). Twenty-seven middle-aged patients with newly diagnosed type 2 diabetes and 27 healthy controls underwent physical measurements and neuropsychological tasks. Response inhibition, reward prediction, and executive function were assessed by the Go/NoGo task, the reversal and extinction tasks, and the Wisconsin Card Sorting Test (WCST). To examine the interactions of being overweight with diabetes on cognitive performance, performance data were analysed by two-way ANCOVA with diabetes and overweight as factors and age as a covariate. Patients with type 2 diabetes showed significantly decreased response inhibition in the Go/NoGo task (discriminability index: P = 0.001). There was an interaction of being overweight with diabetes on reaction time in the Go trials of the Go/NoGo task (P = 0.009). Being overweight was related to retained responses to the presentiment of reward in the extinction task (P = 0.029). The four groups showed normal cognitive performance in the WCST. Our results showed that middle-aged, newly diagnosed and medication-free patients with type 2 diabetes have a particular neuropsychological deficit in inhibitory control of impulsive response, which is an independent effect of diabetes apart from being overweight.