A Preliminary Study on Metadherin as a Potential Marker for Progression of Diffuse Large B Cell Lymphoma.
A Preliminary Study on Metadherin as a Potential Marker for Progression of Diffuse Large B Cell Lymphoma.
复制标题
Metadherin 作为弥漫性大 B 细胞淋巴瘤进展的潜在标志物的初步研究。
DOI：
10.1089/gtmb.2018.0071
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Wang Xin
中科院分区：
文献类型：
--
作者：
Ge Xueling;Sui Xiaohui;Fang Xiaosheng;Jiang Yujie;Ding Mei;Liu Xin;Wang Xin
旨在
基于MTDH在其他类型肿瘤（包括黑色素瘤、恶性胶质瘤、乳腺癌和肝细胞癌）中的高表达，确定Metadherin（MTDH）表达水平是否与弥漫性大B细胞淋巴瘤（DLBCL）的临床分期呈正相关。在这项研究中，我们研究了MTDH的病理意义及其在预测DLBCL预后方面的潜力。
材料和方法
收集了50例DLBCL患者和22例淋巴结反应性增生患者的组织样本，并使用免疫组织化学染色、显微镜和蛋白质印迹法进行评价。采用Kaplan-Meier法和考克斯回归模型进行生存分析。
结果
我们的研究结果表明，在66%的DLBCL患者中观察到MTDH蛋白在组织中的过表达，而在反应性增生淋巴结患者中没有过表达。虽然MTDH过表达与DLBCL患者的年龄、性别、B症状和乳酸脱氢酶（LDH）水平无关，但该参数与临床分期呈正相关。此外，MTDH阴性的患者与MTDH阳性的患者相比，有明显更好的预后。
结论
我们的初步研究表明，MTDH可能在DLBCL的发展中发挥重要作用，MTDH过表达可能与DLBCL的临床进展有关。此外，组织中MTDH的高表达水平与DLBCL患者的预后较差相关。因此，MTDH可能是特异性治疗的潜在治疗靶点。然而，需要对更大的患者群体进行研究来验证这些初步结果。
AIMS
To determine if Metadherin (MTDH) expression levels are positively correlated with the clinical stage of diffuse large B-cell lymphoma (DLBCL) based on MTDH being highly expressed in other type of tumors including melanoma, malignant glioma, breast cancer, and hepatocellular carcinoma. In this study, we investigated the pathologic significance of MTDH and its potential in predicting DLBCL outcomes.
MATERIALS AND METHODS
Tissue samples from 50 patients with DLBCL and 22 patients with lymph node reactive hyperplasia were collected and evaluated using immunohistochemical staining, microscopy, and western blotting. The Kaplan-Meier method and Cox regression model were used for survival analysis of patients.
RESULTS
Our results show that the overexpression of the MTDH protein in tissues was observed in 66% of patients with DLBCL, whereas it was not overexpressed in the patients with reactive hyperplastic lymph nodes. While there was no correlation between MTDH overexpression with age, sex, presence of B symptoms, and lactate dehydrogenase (LDH) levels in patients with DLBCL, this parameter was positively correlated with clinical stages. Moreover, MTDH-negative patients had significantly better prognoses compared with the MTDH-positive patients.
CONCLUSION
Our preliminary study indicates that MTDH may play an important role in the development of DLBCL, and that MTDH overexpression is potentially associated with the clinical progression of DLBCL. In addition, high expression levels of MTDH in tissues was correlated with a poorer prognosis for patients with DLBCL. As such, MTDH may be a potential therapeutic target for specific therapy. However, research on a larger group of patients is needed to verify these preliminary results.
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