Future Directions for Understanding Adolescent Bipolar Spectrum Disorders: A Reward Hypersensitivity Perspective
Future Directions for Understanding Adolescent Bipolar Spectrum Disorders: A Reward Hypersensitivity Perspective
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DOI：
10.1080/15374416.2019.1567347
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发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Nusslock, Robin
中科院分区：
文献类型：
--
作者：
Alloy, Lauren B.;Nusslock, Robin
双相谱系障碍（BSD）的特点是对奖励刺激的敏感性增强，这是奖励超敏反应模型的核心，这是BSD最突出和最受支持的理论之一。在这篇文章中，我们提出了奖励超敏模型的BSD，审查支持它的证据，讨论其相关性，解释为什么BSD通常开始和巩固在青春期期间，并考虑三个主要的未解决的问题，为未来的研究提供了重要的方向。最后，我们提出了整合的奖励超敏反应模型与昼夜节律和免疫系统模型，应该提供更多的了解参与BSD的机制，然后建议未来的研究从这些综合模型的其他方向。
The idea that bipolar spectrum disorders (BSDs) are characterized by enhanced sensitivity to rewarding stimuli is at the core of the reward hypersensitivity model, one of the most prominent and well-supported theories of BSDs. In this article, we present the reward hypersensitivity model of BSDs, review evidence supporting it, discuss its relevance to explaining why BSDs typically begin and consolidate during the period of adolescence, and consider three major unresolved issues for this model that provide important directions for future research. Finally, we present integrations of the reward hypersensitivity model with circadian rhythm and immune system models that should provide greater understanding of the mechanisms involved in BSDs, and then suggest additional directions for future research deriving from these integrated models.