Circulating Tumor Cells for Predicting the Prognostic of Patients with Hepatocellular Carcinoma: A Meta Analysis
Circulating Tumor Cells for Predicting the Prognostic of Patients with Hepatocellular Carcinoma: A Meta Analysis
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DOI：
10.1159/000430382
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发表时间：
2015-01-01
影响因子：
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通讯作者：
Wang, Fu-Bing
中科院分区：
文献类型：
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作者：
Fan, Jun-Li;Yang, Yi-Fei;Wang, Fu-Bing
背景/目的：在肝细胞癌(HCC)患者中检测循环肿瘤细胞(CTC)的预后价值目前仍存在争议。我们对现有研究进行了荟萃分析，以评估其对诊断为肝细胞癌的患者的预后价值。方法：检索Medline、Ovid数据库、Embase、科学引文索引和Cochrane图书馆。这些研究是根据纳入/排除标准设立的。采用随机效应模型，以危险比(HR)、风险比(RR)及其95%可信区间(95%CI)作为效应指标进行Meta分析。对每个合并分析进行研究的异质性检验。同时进行亚组分析和敏感性分析。结果：这项荟萃分析纳入了23项符合选择标准的已发表研究。CTC阳性与无复发生存率(RFS)显著相关(HR 3.03，95%CI：[1.89-4.86]；p
Background/Aims: The prognostic value of circulating tumor cells (CTC) detected in hepatocellular carcinoma (HCC) patients is currently under debate. We conducted a metaanalysis of available studies to assess its prognostic value for patients diagnosed with HCC. Methods: Medline, Ovid Database, Embase, The Science Citation Index, and Cochrane library, search was conducted on all studies reporting the outcomes of interest. The studies were set up according to the inclusion/exclusion criteria. Using a random-effects model, meta-analysis was performed using hazard ratio (HR), risk ratio (RR) and their 95% confidence intervals (95% CIs) as effect measures. Heterogeneity of the studies was tested for each pooled analysis. Subgroup and sensitivity analyses were also performed. Results: twenty-three published studies that matched the selection criteria were included in this meta-analysis. CTC positivity was significantly associated with Relapse free survival (RFS) (HR 3.03, 95% CI: [1.89-4.86]; p