ACUTE EFFECTS OF ACETAZOLAMIDE ON CEREBRAL BLOOD-FLOW VELOCITY AND PCO2 IN THE NEWBORN-INFANT
ACUTE EFFECTS OF ACETAZOLAMIDE ON CEREBRAL BLOOD-FLOW VELOCITY AND PCO2 IN THE NEWBORN-INFANT
复制标题
DOI：
10.1111/j.1651-2227.1991.tb11724.x
复制
发表时间：
1991-01-01
期刊：
影响因子：
--
通讯作者：
WHITELAW, A
中科院分区：
文献类型：
--
作者：
COWAN, F;WHITELAW, A
应用乙酰唑胺治疗婴幼儿脑积水12例。静脉注射组大脑中动脉血流速度增加中位数为86%(范围54-150%)。最大升幅在2~20min内达到最大。这一效果持续了长达3.5小时。颅内压升高中位数为4毫米汞柱(范围0-10毫米汞)。血压和心率没有明显变化。在肺部正常的婴儿中，呼吸频率增加了大约10次/分钟，tcpCO2增加了中位数0.2kpa。口服治疗的婴儿，在60-80分钟内血流速度增加35-40%，而颅内压无增加。在4名患有肺部疾病的婴儿中，二氧化碳分压上升的中位数为2.0千帕(范围为0.6至3.4千帕)。在肺部正常的婴儿中，乙酰唑胺耐受性良好，但在出现肺部疾病时应谨慎使用。
Twelve infants with hydrocephalus were treated with acetazolamide. In those treated intravenously middle cerebral artery blood flow velocity increased by a median of 86% (range 54-150%). Maximum increase was reached within 2-20 min. The effect lasted as long as 3.5 hours. Intracranial pressure rose by a median of 4 mmHg (range 0-10 mmHg). There was no significant alteration in blood pressure or heart rate. Respiratory rate increased by approximately 10 breaths/min and the tcpCO2 rose by a median 0.2 kPa in infants with normal lungs. In infants treated orally, blood velocity rose by 35-40 % at 60-80 min with no increase in intracranial pressure. In four infants with lung disease pCO2 rose by a median of 2.0 kPa (range 0.6 to 3.4 kPa). Acetazolamide was well tolerated in infants with normal lungs but should be used with caution in the presence of lung disease.