Suppressive efficacy by a commercially available blue lens on PPR in 610 photosensitive epilepsy patients
Suppressive efficacy by a commercially available blue lens on PPR in 610 photosensitive epilepsy patients
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DOI：
10.1111/j.1528-1167.2006.00463.x
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发表时间：
2006-03-01
期刊：
影响因子：
5.6
通讯作者：
Tassinari, CA
中科院分区：
文献类型：
--
作者：
Capovilla, G;Gambardella, A;Tassinari, CA
目的：光敏性是癫痫患者的一个严重问题，也是因为药物治疗往往无效。使用蓝色太阳镜的非药物治疗是有效和安全的控制光敏性，但大系列的患者从来没有研究过。方法：这项多中心研究进行了12个癫痫中心在北方，中部，南部和岛屿意大利。在之前的试验中获得的一种名为Z1的市售透镜用于测试连续入组的具有光敏性的儿科和成人癫痫患者。研究中仅考虑了4型光敏性（光阵发性反应，PPR）。结果：610例癫痫患者接受了光刺激测试。400例（66%）为女性患者; 396例（65%）年龄小于14岁。381例（62%）受试者在研究时接受了重复治疗。Z1镜片使463例（75.9%）患者的PPR消失，另外109例（17.9%）患者的PPR显著降低。仅其余38例（6.2%）患者的PPR保持不变。PPR对Z1镜片的反应不受患者年龄、性别或癫痫类型的显著影响。没有发现差异之间的治疗和未治疗的patients.Conclusions：Z1透镜是非常有效的控制PPR在一个非常大的数量的光敏性癫痫患者，无论他们的癫痫或抗癫痫药物治疗。透镜可能成为任何临床医生谁照顾癫痫患者的日常活动的有效资源。
Purpose: Photosensitivity can represent a serious problem in epilepsy patients, also because pharmacologic treatment is often ineffective. Nonpharmacologic treatment using blue sunglasses is effective and safe in controlling photosensitivity, but large series of patients have never been studied.Methods: This multicenter study was conducted in 12 epilepsy centers in northern, central, southern, and insular Italy. A commercially available lens, named Z1, obtained in a previous trial, was used to test consecutively enrolled pediatric and adult epilepsy patients with photosensitivity. Only type 4 photosensitivity (photoparoxysmal response, PPR) was considered in the study. A standardized method was used for photostimulation.Results: Six hundred ten epilepsy patients were tested. Four hundred (66%) were female patients; 396 (65%) were younger than 14 years. Three hundred eighty-one (62%) subjects were pharmacologically treated at the time of investigation. Z1 lenses made PPR disappear in 463 (75.9%) patients, and PPR was considerably reduced in an additional 109 (17.9%) of them. PPR remained unchanged only in the remaining 38 (6.2%) patients. The response of PPR to Z1 lenses was not significantly influenced by the patients' age, sex, or type of epilepsy. No difference was found between pharmacologically treated and untreated patients.Conclusions: The Z1 lens is highly effective in controlling PPR in a very large number of photosensitive epilepsy patients irrespective of their epilepsy or antiepileptic drug treatment. The lens might become a valid resource in the daily activity of any clinician who cares for patients with epilepsy.