Tuning surface properties of bone biomaterials to manipulate osteoblastic cell adhesion and the signaling pathways for the enhancement of early osseointegration
Tuning surface properties of bone biomaterials to manipulate osteoblastic cell adhesion and the signaling pathways for the enhancement of early osseointegration
复制标题
调整骨生物材料的表面特性以操纵成骨细胞粘附和信号通路以增强早期骨整合
DOI：
10.1016/j.colsurfb.2018.01.022
复制
发表时间：
2018-04-01
影响因子：
5.8
通讯作者：
Chen, Zetao
中科院分区：
文献类型：
--
作者：
Chen, Shoucheng;Guo, Yuanlong;Chen, Zetao
成骨细胞黏附是骨材料植入后早期骨整合的初始步骤。提高成骨细胞的粘附性已成为优化骨生物材料表面性能的主要目标之一。传统的策略侧重于改善成骨细胞在生物材料表面的物理附着。然而，成骨细胞的黏附不是简单的细胞物理附着，而是一个复杂的系统。尽管骨生物材料表面修饰对粘连的影响已有文献记载，但很少有研究关注其潜在的分子机制。来自生物材料的物理化学信号可以被传导到细胞内的信号网络，进而启动对植入物的早期反应级联反应，包括细胞存活、迁移、增殖和分化。粘附性是决定宿主骨组织与植入骨生物材料之间早期骨结合的关键因素，涉及信号通路的调控。因此，对早期黏附行为的调控不应单纯针对物理附着，而应强调对下游信号通路的操纵，以调节早期骨整合。本文首先综述了成骨细胞黏附过程的基本生物学原理和激活的下游细胞信号通路。并对不同生物材料的理化性质对成骨细胞黏附的影响进行了综述。本文综述了成骨细胞在不同物理化学性质的骨生物材料上黏附行为的最新研究成果。该策略从传统的侧重于物理细胞黏附的策略优化为操纵细胞黏附和下游信号网络以促进早期骨整合的建议策略。(C)2018爱思唯尔B.V.保留所有权利。
Osteoblast cell adhesion is the initial step of early osseointegration responding to bone material implants. Enhancing the osteoblastic cell adhesion has become one of the prime aims when optimizing the surface properties of bone biomaterials. The traditional strategy focuses in improving the physical attachment of osteoblastic cells onto the surfaces of biomaterials. However, instead of a simple cell physical attachment, the osteoblastic cell adhesion has been revealed to be a sophisticated system. Despite the well-documented effect of bone biomaterial surface modifications on adhesion, few studies have focused on the underlying molecular mechanisms. Physicochemical signals from biomaterials can be transduced into intracellular signaling network and further initiate the early response cascade towards the implants, which includes cell survival, migration, proliferation, and differentiation. Adhesion is vital in determining the early osseointegration between host bone tissue and implanted bone biomaterials via regulating involving signaling pathways. Therefore, the modulation of early adhesion behavior should not simply target in physical attachment, but emphasize in the manipulation of downstream signaling pathways, to regulate early osseointegration. This review firstly summarized the basic biological principles of osteoblastic cell adhesion process and the activated downstream cell signaling pathways. The effects of different biomaterial physicochemical properties on osteoblastic cell adhesion were then reviewed. This review provided up-to-date research outcomes in the adhesion behavior of osteoblastic cells on bone biomaterials with different physicochemical properties. The strategy is optimised from traditionally focusing in physical cell adhesion to the proposed strategy that manipulating cell adhesion and the downstream signaling network for the enhancement of early osseointegration. (C) 2018 Elsevier B.V. All rights reserved.