Exercise improves recognition memory and synaptic plasticity in the prefrontal cortex for rats modelling vascular dementia
Exercise improves recognition memory and synaptic plasticity in the prefrontal cortex for rats modelling vascular dementia
复制标题
运动可改善血管性痴呆模型大鼠前额皮质的识别记忆和突触可塑性
DOI：
10.1080/01616412.2017.1398389
复制
发表时间：
2018-01-01
影响因子：
1.9
通讯作者：
Yan, Tiebin
中科院分区：
文献类型：
--
作者：
Dong, Juntao;Zhao, Jingpu;Yan, Tiebin
摘要目标：功能性电刺激（functional electrical stimulation，FES）可能通过增强BDNF-pCREB介导的通路和海马可塑性，诱导不自主运动，从而对血管性痴呆（vascular dementia，VD）产生有益的影响。通过建立VD动物模型，研究FES是否能改善前额叶皮层（PFC）的再认记忆和突触可塑性。方法：采用自由运动、强迫运动和FES诱导的不自主运动，对VD大鼠进行两周的运动训练。还包括假手术组和对照组。采用新物体再认测验和新物体定位测验评价行为学变化。并检测了与突触可塑性相关的关键蛋白在PFC中的表达水平。结果如下：所有类型的运动都能提高大鼠的新物体识别指数，但只有自主运动和FES诱导的非自主运动能提高新物体定位指数。结论：FES诱导的不自主运动能更好地改善VD患者的再认记忆。该机制与PFC中突触可塑性增加有关。FES可能是一种有用的认知康复替代工具。
Abstract Objectives: Functional electrical stimulation (FES) may induce involuntary exercise and make beneficial effects on vascular dementia (VD) by strengthening the BDNF-pCREB-mediated pathway and hippocampal plasticity. Whether FES improves recognition memory and synaptic plasticity in the prefrontal cortex (PFC) was investigated by establishing a VD model. Methods: The VD rats were administered with two weeks of voluntary exercise, forced exercise, or involuntary exercise induced with FES. Sham-operated and control groups were also included. The behavioral changes were assessed with the novel object recognition test and novel object location test. The expression levels of key proteins related to synaptic plasticity in the PFC were also detected. Results: All types of exercise improved the rats’ novel object recognition index, but only voluntary exercise and involuntary exercise induced with FES improved the novel object location index. Any sort of exercise enhanced the expression of key proteins in the PFC. Conclusion: Involuntary exercise induced with FES can improve recognition memory in VD better than forced exercise. The mechanism is associated with increased synaptic plasticity in the PFC. FES may be a useful alternative tool for cognitive rehabilitation.