The salt-inducible kinase, SIK, is induced by depolarization in brain
The salt-inducible kinase, SIK, is induced by depolarization in brain
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DOI：
10.1046/j.1471-4159.2000.0742227.x
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发表时间：
2000-06-01
影响因子：
4.7
通讯作者：
Herschman, HR
中科院分区：
文献类型：
--
作者：
Feldman, JD;Vician, L;Herschman, HR
神经元的膜去极化被认为会导致调节神经元可塑性的基因表达的变化，我们使用代表性差异分析在PC12嗜铬细胞瘤细胞中鉴定了一组由膜去极化或Forsklin诱导而不是由神经营养素或生长因子诱导的cDNA。其中SIK(S)是最近从高盐饮食大鼠的肾上腺中发现的非蔗糖发酵1蛋白激酶/腺苷活化蛋白激酶蛋白激酶家族的成员。在全身给药和癫痫诱导后，在大鼠的海马区和大脑皮层的特定区域中，SIK mRNA被表达高达8倍。
Membrane depolarization of neurons is thought to lead to changes in gene expression that modulate neuronal plasticity, We used representational difference analysis to identify a group of cDNAs that are induced by membrane depolarization or by forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. One of these genes, SIK ((s) over bar alt-(i) over bar nducible (k) over bar inase), is a member of the sucrose-nonfermenting 1 protein kinase/AMP-activated protein kinase protein kinase family that was also recently identified from the adrenal gland of rats treated with high-salt diets. SIK mRNA is induced up to eightfold in specific regions of the hippocampus and cortex in rats, following systemic kainic acid administration and seizure induction.