Are EBV-related and EBV-unrelated Hodgkin lymphomas different with regard to susceptibility to checkpoint blockade?
Are EBV-related and EBV-unrelated Hodgkin lymphomas different with regard to susceptibility to checkpoint blockade?
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DOI：
10.1182/blood-2018-02-833806
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发表时间：
2018-07-05
期刊：
影响因子：
20.3
通讯作者：
Carlo-Stella, Carmelo
中科院分区：
文献类型：
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作者：
Carbone, Antonino;Gloghini, Annunziata;Carlo-Stella, Carmelo
EB 病毒 (EBV) 相关和 EBV 无关经典霍奇金淋巴瘤 (cHL) 在形态和表型上无法区分。然而，与 EBV 无关的 cHL 相比，EBV 相关 cHL 的肿瘤微环境含有更多数量的巨噬细胞和更高的 PD-L1 表达水平。此外，病毒癌蛋白LMP1可以通过诱导/增强免疫抑制细胞因子的产生和PD-1的表达来维持免疫抑制微环境。 EBV 相关 cHL 中增强的免疫抑制特征应该使 EBV 相关 cHL 患者更容易受到检查点阻断的影响。
Epstein-Barr virus (EBV)-related and EBV-unrelated classical Hodgkin lymphomas (cHLs) are morphologically and phenotypically indistinguishable. However, the tumor microenvironment of EBV-related cHLs contains higher numbers of macrophages and higher expression levels of PD-L1 than that of EBV-unrelated cHLs. Moreover, viral oncoprotein LMP1 may sustain an immunosuppressive microenvironment by inducing/enhancing production of immunosuppressive cytokines and the expression of PD-1. The presence of enhanced immunosuppressive features in EBV-related cHL should make EBV-related cHL patients more susceptible to checkpoint blockade.