Effect of hydrazine sulphate on whole-body protein breakdown measured by 14C-lysine metabolism in lung cancer patients.
Effect of hydrazine sulphate on whole-body protein breakdown measured by 14C-lysine metabolism in lung cancer patients.
复制标题
硫酸肼对肺癌患者 14C-赖氨酸代谢测量的全身蛋白质分解的影响。
DOI：
10.1016/s0140-6736(87)90828-2
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Chlebowski,RT
中科院分区：
文献类型：
--
作者：
Tayek,JA;Heber,D;Chlebowski,RT
In a prospective double-blind trial twelve malnourished patients with lung cancer were randomised to receive either placebo or hydrazine sulphate (60 mg three times daily) for 30 days. Fasting lysine flux was determined by a primed 4-hour continuous infusion of14C-lysine before and after one month of hydrazine treatment. Baseline plasma lysine flux was 2580 (SD 580) μmol/h for the placebo group and 2510 (440) μmol/h for the hydrazine group. After one month the placebo group showed a slight rise to 2920 (450) μmol/h (p = 0·08) and the hydrazine group showed a significant fall to 1840 (750) μmol/h (p <0·05); serum albumin fell in the placebo group and was unchanged in the hydrazine group. Administration of hydrazine sulphate to reduce aminoacid flux may favourably influence the metabolic abnormalities in cancer cachexia.
