Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system.
Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system.
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DOI：
10.2217/fmb.15.32
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发表时间：
2015
影响因子：
3.1
通讯作者：
Fischer W
中科院分区：
文献类型：
--
作者：
Backert S;Tegtmeyer N;Fischer W
许多革兰氏阴性病原体具有IV型分泌系统（T4 SS），其将细菌毒力因子转运到宿主细胞中以劫持细胞过程。胃病原体幽门螺杆菌的病理学强烈依赖于由cag致病岛编码的T4 SS。这种T4 SS形成针状菌毛，其组装是通过多种蛋白质-蛋白质相互作用和各种菌毛相关因子与整合素结合，然后将CagA癌蛋白递送到胃上皮细胞中来完成的。最近的研究表明，六个T4 SS蛋白的晶体结构和菌毛的形成是由铁和锌的可用性调制。所有这些T4 SS相互作用对于解除宿主信号传导事件和疾病进展至关重要。T4 SS功能的新发展及其对发病机制的重要性进行了讨论。
Many Gram-negative pathogens harbor type IV secretion systems (T4SS) that translocate bacterial virulence factors into host cells to hijack cellular processes. The pathology of the gastric pathogen Helicobacter pylori strongly depends on a T4SS encoded by the cag pathogenicity island. This T4SS forms a needle-like pilus, and its assembly is accomplished by multiple protein–protein interactions and various pilus-associated factors that bind to integrins followed by delivery of the CagA oncoprotein into gastric epithelial cells. Recent studies revealed the crystal structures of six T4SS proteins and pilus formation is modulated by iron and zinc availability. All these T4SS interactions are crucial for deregulating host signaling events and disease progression. New developments in T4SS functions and their importance for pathogenesis are discussed.