Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS
Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS
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多囊卵巢综合征女性的脂肪胰岛素抵抗和循环 Betatropin 水平
DOI：
10.1155/2020/1253164
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发表时间：
2020-01-22
影响因子：
--
通讯作者：
Li Ling
中科院分区：
文献类型：
--
作者：
He Yirui;Hu Wenjin;Li Ling
IR和代谢紊乱在PCOS发病机制中的作用已成为一个重要的研究课题。脂肪组织是胰岛素的重要靶器官，脂肪IR在PCOS的发生发展中起重要作用。本研究旨在探讨脂肪IR在PCOS发展中的作用，并研究其与PCOS女性循环betatrophin水平的关系。在这项研究中，对一组PCOS妇女和健康妇女进行了横断面分析。通过ELISA测量血清betatrophin浓度。采用空腹胰岛素和游离脂肪酸浓度的乘积计算脂肪IR，并分析脂肪IR、循环β-营养素与其他参数之间的关系。PCOS组脂肪IR明显高于对照组。我们发现有脂肪IR（脂肪IR ≥ 55）的PCOS患者的BMI和血糖、胰岛素、PRL、FFA、TG、HOMA-IR、AUC葡萄糖、AUC胰岛素、VAI女性和BAI水平高于无脂肪IR的PCOS患者，而M值、SHBG和LH水平较低。PCOS患者血清betatrophin水平显著高于对照组。在研究人群中，脂肪IR与M值呈负相关，与循环betatrophin水平呈正相关。二甲双胍治疗后，PCOS女性的循环betatrophin水平和脂肪IR与治疗前相比显著降低。PCOS女性脂肪IR与betatrophin水平相关脂肪IR和循环betatrophin测量的结合对于筛查PCOS患者可能具有重要意义。
The role of IR and metabolic disorders has become a crucial topic of study in the pathogenesis of PCOS. Adipose tissue is an important target organ of insulin, and adipose IR plays an important role in the occurrence and development of PCOS. This study seeks to investigate the role of adipose IR in the development of PCOS and to examine its relationship with circulating betatrophin levels in women with PCOS. A cross-sectional analysis of a cohort of women with PCOS and healthy women was performed in this study. Serum betatrophin concentrations were measured by ELISA. Adipose IR was calculated using the product of fasting insulin and FFA concentrations, and the relationship between adipose IR, circulating betatrophin, and other parameters was analyzed. Adipose IR in women with PCOS was significantly higher than that in controls. We found that women with PCOS who have adipose IR (adipose IR ≥ 55) have a higher BMI and higher blood glucose, insulin, PRL, FFA, TG, HOMA-IR, AUCglucose, AUCinsulin, VAIfemale, and BAI levels than PCOS-afflicted women without adipose IR, while M-values, and SHBG and LH levels were lower. In women with PCOS, serum betatrophin levels were significantly increased compared with controls. Adipose IR negatively correlated with M values and positively with circulating betatrophin levels in the study population. After metformin treatment, circulating betatrophin levels and adipose IR in women with PCOS were significantly decreased compared with pretreatment. Adipose IR is associated with betatrophin levels in women with PCOS. The combination of adipose IR and circulating betatrophin measurements may be significant for screening patients with PCOS.