Particulate matter air pollution exposure: role in the development and exacerbation of chronic obstructive pulmonary disease.
Particulate matter air pollution exposure: role in the development and exacerbation of chronic obstructive pulmonary disease.
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DOI：
10.2147/copd.s5098
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发表时间：
2009
影响因子：
2.8
通讯作者：
van Eeden SF
中科院分区：
文献类型：
--
作者：
Ling SH;van Eeden SF
由于世界人口的快速城市化，有必要更好地了解暴露于城市空气污染对慢性肺病的有害影响。强有力的流行病学证据表明，接触颗粒物（PM）空气污染会导致原有肺部疾病（如慢性阻塞性肺疾病）恶化，从而导致发病率和死亡率增加。然而，人们对慢性、低浓度暴露于环境PM是否会导致COPD的发生和发展知之甚少。PM在呼吸道的沉积主要取决于颗粒的大小，较大的颗粒沉积在上气道和大气道，较小的颗粒深入肺泡间隙。从气道中清除这种PM的无效可能导致颗粒滞留在肺组织中，导致慢性、低度炎症反应，这可能在肺部疾病的加重和进展中具有重要的病理意义。这篇综述的重点是暴露于环境PM空气污染对COPD的恶化、进展和发展的不利影响。
Due to the rapid urbanization of the world population, a better understanding of the detrimental effects of exposure to urban air pollution on chronic lung disease is necessary. Strong epidemiological evidence suggests that exposure to particulate matter (PM) air pollution causes exacerbations of pre-existing lung conditions, such as, chronic obstructive pulmonary disease (COPD) resulting in increased morbidity and mortality. However, little is known whether a chronic, low-grade exposure to ambient PM can cause the development and progression of COPD. The deposition of PM in the respiratory tract depends predominantly on the size of the particles, with larger particles deposited in the upper and larger airways and smaller particles penetrating deep into the alveolar spaces. Ineffective clearance of this PM from the airways could cause particle retention in lung tissues, resulting in a chronic, low-grade inflammatory response that may be pathogenetically important in both the exacerbation, as well as, the progression of lung disease. This review focuses on the adverse effects of exposure to ambient PM air pollution on the exacerbation, progression, and development of COPD.