Relationship between choline and apparent diffusion coefficient in patients with gliomas
Relationship between choline and apparent diffusion coefficient in patients with gliomas
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DOI：
10.1002/jmri.21288
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发表时间：
2008-04-01
影响因子：
4.4
通讯作者：
Nelson, Sarah J.
中科院分区：
文献类型：
--
作者：
Khayal, Inas S.;Crawford, Forrest W.;Nelson, Sarah J.
目的：为探讨不同解剖部位的Ⅱ、Ⅳ级胶质瘤的扩散加权成像（DWI）表观扩散系数（ADC）与质子磁共振波谱成像（MRSI）胆碱水平之间的关系，对37例Ⅱ级和28例Ⅳ级胶质瘤患者行1.5T磁共振波谱成像（MRSI）和3D DWI扫描。区域水平分析包括在每个不同的异常解剖区域内每个等级的每例患者的中值标准化ADC和胆碱之间的斯皮尔曼等级相关性。体素水平分析计算了斯皮尔曼等级相关性，每个区域，patient.Results：II级病变显示，没有证据表明，使用区域或体素水平分析之间的相关性的标准化ADC和胆碱。区域水平分析等级TV病变并没有出现相关的对比增强或坏死核心，但确实表明在更异质性的nonenhancing和组合regions.Conclusion：，ADC和胆碱水平之间的关系出现差异，在等级II和IV胶质瘤。当包括所有区域时，IV级病变中这些区域内的相关性最强，表明异质性可能是驱动关系的原因。
Purpose: To examine the relationship between apparent diffusion coefficients (ADC) from diffusion weighted imaging (DWI) and choline levels from proton magnetic resonance spectroscopic imaging (MRSI) in newly diagnosed Grade II and IV gliomas within distinct anatomic regions.Materials and Methods: A total of 37 patients with Grade II and 28 patients with Grade IV glioma were scanned on a 1.5T system with 3D MRSI and DWI. Region level analysis included Spearman rank correlation between median normalized ADC and choline for each patient per grade within each distinct abnormal anatomical region. Voxel level analysis calculated a Spearman rank correlation per region, per patient.Results: Grade II lesions showed no evidence of a correlation between normalized ADC and choline using either the region or voxel level analysis. Region level analysis of Grade TV lesions did not appear to correlate in the contrast enhancement or necrotic core, but did suggest a significant negative correlation in the more heterogeneous nonenhancing and combined regions.Conclusion:, There appears to be differences in the relationship between ADC and choline levels in Grade II and Grade IV gliomas. Correlation within these regions in Grade IV lesions was strongest when all regions were included, suggesting heterogeneity may be driving the relationship.