Molecular clocks, satellite cells, and skeletal muscle regeneration.
Molecular clocks, satellite cells, and skeletal muscle regeneration.
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分子钟、卫星细胞和骨骼肌再生。
DOI：
10.1152/ajpcell.00073.2023
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Hawley,JohnA
中科院分区：
文献类型：
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作者：
Kahn,RyanE;Dayanidhi,Sudarshan;Lacham-Kaplan,Orly;Hawley,JohnA
骨骼肌约占个体体重的50%，在运动、产热和全身代谢动态平衡中起着重要作用。这种组织表现出强健的昼夜节律，由下丘脑的视交叉上核(SCN)区域控制。SCN充当昼夜节律的“中央”协调器，而细胞自主的“外周”时钟几乎位于身体所有其他组织/器官内。肌肉(和其他组织)的外周时钟与中央时钟的同步对于确保所有器官系统的时间协调生理学至关重要。就其质量而言，人类骨骼肌包含最大的外周时钟集合，但在肌肉中驻留着一个局部干细胞群体，卫星细胞(SC)，它们有自己的功能分子时钟，独立于众多的肌肉时钟。骨骼肌每天的周转率为1%-2%，因此该组织的再生能力对全身的动态平衡/修复非常重要，并依赖于成功的SC肌原进展(即增殖、分化和融合)。新出现的证据表明，SC介导的肌肉再生可能在一定程度上受到参与SC特异性每日转录的分子时钟的调控。在这里，我们提供了对肌肉再生/修复的分子时钟调节的见解，并提供了一个新的视角，揭示了支持肌肉再生/修复的SC特异性分子时钟、成肌程序和细胞周期动力学之间的相互作用。
Skeletal muscle comprises approximately 50% of individual body mass and plays vital roles in locomotion, heat production, and whole body metabolic homeostasis. This tissue exhibits a robust diurnal rhythm that is under control of the suprachiasmatic nucleus (SCN) region of the hypothalamus. The SCN acts as a “central” coordinator of circadian rhythms, while cell-autonomous “peripheral” clocks are located within almost all other tissues/organs in the body. Synchronization of the peripheral clocks in muscles (and other tissues) together with the central clock is crucial to ensure temporally coordinated physiology across all organ systems. By virtue of its mass, human skeletal muscle contains the largest collection of peripheral clocks, but within muscle resides a local stem cell population, satellite cells (SCs), which have their own functional molecular clock, independent of the numerous muscle clocks. Skeletal muscle has a daily turnover rate of 1%–2%, so the regenerative capacity of this tissue is important for whole body homeostasis/repair and depends on successful SC myogenic progression (i.e., proliferation, differentiation, and fusion). Emerging evidence suggests that SC-mediated muscle regeneration may, in part, be regulated by molecular clocks involved in SC-specific diurnal transcription. Here we provide insights on molecular clock regulation of muscle regeneration/repair and provide a novel perspective on the interplay between SC-specific molecular clocks, myogenic programs, and cell cycle kinetics that underpin myogenic progression.