Psychoneuroimmunological correlates of persisting sciatic pain in patients who underwent discectomy
Psychoneuroimmunological correlates of persisting sciatic pain in patients who underwent discectomy
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DOI：
10.1016/s0304-3940(97)00810-0
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发表时间：
1997-11-21
影响因子：
2.5
通讯作者：
Anton, F
中科院分区：
文献类型：
--
作者：
Geiss, A;Varadi, E;Anton, F
将椎间盘切除术后8周持续坐骨神经痛的患者与低主诉患者和健康无痛志愿者的白细胞介素-6（IL-6）水平、早晨皮质醇水平和心理困扰程度进行比较。而IL-6的血清浓度测定通过收集血液样本之间的0945和2400小时的间隔为45分钟，早晨皮质醇水平通过采样唾液五个随后的测量，立即开始后觉醒。此外，调查问卷旨在测量抑郁情绪，躯体症状，应对和慢性压力填写的主题。与其他两组相比，持续疼痛的患者在觉醒后显示出显著升高的IL-6水平和减弱的皮质醇分泌升高。持续疼痛的患者也更频繁地遭受抑郁情绪和持续的工作相关的压力。此外，适应不良的应对策略，这些患者的青睐。所提供的数据支持的假设，在许多有关患者的疼痛的持续性可能显着相关的神经，内分泌和免疫功能之间的功能失调的相互关系。(C)1997 Elsevier Science爱尔兰有限公司
Patients suffering from persisting sciatic pain 8 weeks following discectomy were compared with patients displaying low complaints and healthy, pain-free volunteers regarding their interleukin-6 (IL-6) levels, morning cortisol levels and degree of psychological distress. Whereas serum concentrations of IL-6 were measured by collecting blood samples between 0945 and 2400 h in intervals of 45 min, morning cortisol levels were obtained by sampling saliva on five ensuing measurements, beginning immediately after awakening. In addition, questionnaires aimed at measuring depressive mood, somatic symptoms, coping and chronic stress were filled out by the subjects. The patients with ongoing pain displayed significantly elevated IL-6 levels and an attenuated elevation of cortisol secretion after awakening compared to the two other groups. Patients with persisting pain were also suffering more frequently from depressive mood and ongoing work-related strains. In addition, maladaptive coping strategies were favoured by these patients. The presented data support the hypothesis that the persistence of pain in many of the concerned patients may significantly be related to dysfunctional reciprocal relations between neural, endocrine and immune function. (C) 1997 Elsevier Science Ireland Ltd.