Age- and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation.
Age- and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation.
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DOI：
10.1371/journal.pone.0148812
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Nakazawa T
中科院分区：
文献类型：
--
作者：
Aizawa N;Kunikata H;Nitta F;Shiga Y;Omodaka K;Tsuda S;Nakazawa T
目的 研究正常人群的各种特征与视神经乳头 (ONH) 平均模糊率 (MBR) 的激光散斑血流成像 (LSFG) 测量之间的关系。纳入无高血压、高脂血症或糖尿病病史的 189 名正常受试者（男性 93 例，女性 96 例，平均年龄 45 ± 14 岁，年龄范围：20-72 岁）共 189 只眼。使用 LSFG 测量 ONH 微循环，并从这些测量中得出总体 MBR (MA)、血管区域 MBR (MV) 和组织区域 MBR (MT)。然后确定这些测量值与性别、年龄、眼内压（IOP）和收缩压（SBP）等特征的统计关联。随着年龄的增长，IOP 和 MV 呈下降趋势，SBP 呈上升趋势（分别为 P = 0.002、P = 0.035 和 P = 0.006）。此外，IOP、MV 和 SBP 与年龄相关（分别为 r = -0.23，P = 0.011；r = -0.24，P < 0.001；r = 0.30，P < 0.001）。对独立影响因素的单独多元回归分析显示，性别和 IOP 影响 MA（分别为 P < 0.001 和 P = 0.002），性别、IOP 和年龄影响 MV（分别为 P < 0.001、P = 0.003 和 P = 0.024），而只有 IOP 影响 MT（P = 0.003）。在正常人群中，ONH 的大血管和毛细血管区域的 MBR 均受 IOP 影响，但不受 SBP 影响。 MV 还受到年龄和性别的影响，而 MT 稳定，与年龄或性别无关。
To investigate the relationship between various characteristics of a normal population and laser speckle flowgraphy (LSFG) measurements of mean blur rate (MBR) in the optic nerve head (ONH). A total of 189 eyes of 189 normal subjects (93 male, 96 female, mean age 45 ± 14 years old, age range: 20–72) without any history of hypertension, hyperlipidemia or diabetes were enrolled. ONH microcirculation was measured with LSFG and overall MBR (MA), vessel-area MBR (MV), and tissue-area MBR (MT) were derived from these measurements. The statistical association of these measurements with characteristics such as sex, age, intraocular pressure (IOP) and systolic blood pressure (SBP) was then determined. There was a trend towards decreased IOP and MV and increased SBP with age (P = 0.002, P = 0.035, and P = 0.006, respectively). Furthermore, IOP, MV and SBP were correlated with age (r = -0.23, P = 0.011; r = -0.24, P < 0.001; and r = 0.30, P < 0.001, respectively). Separate multiple regression analyses of independent contributing factors revealed that sex and IOP contributed to MA (P < 0.001 and P = 0.002, respectively), sex, IOP, and age contributed to MV (P < 0.001, P = 0.003, and P = 0.024, respectively), while only IOP contributed to MT (P = 0.003). In a normal population, MBR was affected by IOP in both the large vessel and capillary areas of the ONH, but not by SBP. MV was also affected by age and sex, while MT was stable independent of age or sex.