Apolipoprotein AV variants do not affect C-reactive protein levels in Caucasian males
Apolipoprotein AV variants do not affect C-reactive protein levels in Caucasian males
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DOI：
10.33549/physiolres.930746
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发表时间：
2005-01-01
影响因子：
2.1
通讯作者：
Poledne, R
中科院分区：
文献类型：
--
作者：
Hubácek, JA;Skodová, Z;Poledne, R
APOAV基因变异在测定血浆甘油三酯水平中的重要作用已在许多人群研究中得到证实。最近，APOAV T-1131 > C多态性对韩国年轻男性C反应蛋白（CRP）的影响有报道。因此，我们分析了1119名年龄在28至67岁（49.2 +/- 10.8岁）的高加索男性中T-1131 > C、Ser19 > Trp和Val153 > Met APOAV变异（PCR和限制性内切分析）与CRP浓度之间的推定关联。白种人携带C等位基因的频率低于韩国人（15.5%比46.2%）。T/T纯合子（n=946, 1.61 +/- 2.05 mg/1）和C等位基因携带者（n=173, 1.67 +/- 1.95 mg/1）之间CRP水平无差异。因此，与韩国男性相比，T-1131 b> C APOAV变异对大量高加索男性的血浆CRP浓度没有影响。其他APOAV变体（Ser19 > Trp和Val153 > Met）也不影响CRP的血浆浓度。APOAV变异不太可能是高加索男性血浆CRP浓度的重要遗传决定因素。
The important role of APOAV gene variants in determination of plasma triglyceride levels has been shown in many population studies. Recently, an influence of APOAV T-1131 > C polymorphism on C-reactive protein (CRP) in young Korean males has been reported. We have therefore analyzed a putative association between T-1131 > C, Ser19 > Trp and Val153 > Met APOAV variants (PCR and restriction analysis) and CRP concentrations in 1119 Caucasian males, aged between 28 and 67 years (49.2 +/- 10.8 years). The frequency of C allele carriers was lower in Caucasians than in Koreans (15.5% vs. 46.2%). CRP levels did not differ between T/T homozygotes (n=946, 1.61 +/- 2.05 mg/1) and carriers of the C allele (n=173, 1.67 +/- 1.95 mg/1). Thus, in contrast to Korean males, T-1131 > C APOAV variant has no effect on plasma concentrations of CRP in a large group of Caucasian males. Other APOAV variants (Ser19 > Trp and Val153 > Met) did not also influence plasma concentrations of CRP. APOAV variants are unlikely to be an important genetic determinant of plasma CRP concentrations in Caucasian males.