Anti-epileptic drug intake adherence - The value of the blood drug level measurement and the clinical approach
Anti-epileptic drug intake adherence - The value of the blood drug level measurement and the clinical approach
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DOI：
10.1590/s0004-282x1998000500002
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发表时间：
1998-12-01
影响因子：
1.4
通讯作者：
Noe, RAM
中科院分区：
文献类型：
--
作者：
Gomes, MD;Maia, HD;Noe, RAM
在一所大学医院的神经科门诊进行的一项试点横断面研究中，对患者抗癫痫药物（AED）摄入依从性进行了评估。分析了24例患者的93种AED血药浓度（苯巴比妥、苯妥英、卡马西平）。测量AED血药浓度的变异性（在稳态期间通过变异系数），并与自我报告的抗癫痫药物不依从性、根据范围（治疗或非治疗）的AED血药浓度和癫痫发作控制进行比较。未观察到变异性较高值与其他三个无依从性参数之间存在任何强相关性。相关性最高的是血药浓度（治疗或非治疗）。除了极低依从性和药物摄入变异性的情况外，单独评价血液药物测量不足以识别不正确的药物摄入，但这种评价还必须考虑临床标志物和自我报告的依从性。
It wets evaluated the patient antiepileptic drug (AED) intake adherence in a pilot cross-sectional study carried out at a neurologic out-patient clinic of a university hospital. Ninety-three AED blood concentration (phenobarbital, phenytoin, carbamazepine) were analyzed from 24 patients. The variability of the AED blood level was measured (in the steady state period by means of the variation coefficient) and compared with the self-reported antiepileptic medication non-adherence, AED blood level according to the range (therapeutic or not), and the seizure control. It was not observed any strong correlation between the higher value of variability and the other three parameters of no adherence. The highest correlation was with the blood drug level (therapeutic or not). The evaluation of blood drug measurement alone, except in cases of extreme low adherence and variability of drug intake, is not enough For the recognition of incorrect drug intake, but the clinical markers and the self-reported adherence have to be also considered for this sort of evaluation.