Reconstruction of the Hematopoietic System after Stem Cell Transplantation
Reconstruction of the Hematopoietic System after Stem Cell Transplantation
复制标题
DOI：
10.1177/096368979800700401
复制
发表时间：
1998-07
影响因子：
3.3
通讯作者：
M.Y. Gordon;N.M. Blackett
中科院分区：
文献类型：
--
作者：
M.Y. Gordon;N.M. Blackett
造血干细胞移植的实践是基于移植物中的造血干细胞有足够的增殖能力来为受者剩余的生命提供成熟的血细胞，以拯救患者摆脱化疗或放射治疗的清髓作用，或取代有缺陷的造血功能。然而，实现这一目标的机制(S)并不是很清楚。在这里，我们通过考虑干细胞和祖细胞更新和分化的影响来重建造血系统。我们得出结论，干细胞自我更新对于血液学恢复是必要的，输注承诺祖细胞(CFU-GM)可能有助于移植后早期的中性粒细胞计数。
The practice of hematopoietic stem cell transplantation to rescue patients from the myeloablative effects of chemo- or radiotherapy, or to replace defective hematopoiesis, is based on the assumption that hematopoietic stem cells in the graft have sufficient proliferative potential to supply mature blood cells for the remainder of the recipient's lifespan. However, the mechanism(s) whereby this is achieved are not well understood. Here we address the reconstruction of the hematopoietic system by considering the effects of stem cell and progenitor cell renewal and differentiation. We conclude that stem cell self-renewal is necessary for hematological recovery and that infused committed progenitor cells (CFU-GM) may contribute to the neutrophil count in the early posttransplant period.