CAN MELATONIN IMPROVE SHIFT WORKERS TOLERANCE OF THE NIGHT-SHIFT - SOME PRELIMINARY FINDINGS
CAN MELATONIN IMPROVE SHIFT WORKERS TOLERANCE OF THE NIGHT-SHIFT - SOME PRELIMINARY FINDINGS
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DOI：
10.3109/07420529309064485
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发表时间：
1993-10-01
影响因子：
2.8
通讯作者：
CLARK, M
中科院分区：
文献类型：
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作者：
FOLKARD, S;ARENDT, J;CLARK, M
松果体激素褪黑激素在治疗与昼夜节律紊乱相关的疾病，特别是睡眠障碍中是潜在有用的。我们已经研究了它对睡眠，情绪和行为的影响，在一个双盲，安慰剂对照的研究中，一小群警察连续七个夜班工作。与安慰剂相比，没有治疗，在理想的就寝时间服用褪黑激素（5毫克）改善了与睡眠有关的问题，并提高了工作时间的警觉性，特别是在清晨。在字母-目标性能测试中，视觉搜索速度和准确性没有变化或略有改善。记忆扫描速度和对精神负荷的感知受到不利影响。这项初步研究表明，褪黑激素对睡眠和警觉性有有益的影响，但其对表现的影响需要仔细评估。
The pineal hormone melatonin is potentially useful in the treatment of disorders, especially sleep disorders, associated with circadian rhythm disturbance. We have examined its effects on sleep, mood, and behaviour in a double-blind, placebo-controlled study of a small group of police officers working spans of seven successive night shifts. Compared to placebo, and to no treatment, melatonin (5 mg) taken at the desired bedtime improved problems related to sleep and increased alertness during working hours, especially during the early morning. In letter-target performance tests visual search speed and accuracy were either unchanged or slightly improved. Memory scanning speed and perception of mental load were adversely affected. This preliminary study suggests that melatonin has beneficial effects on sleep and alertness, but that its effects on performance need careful evaluation.