Peripubertal suicide attempts in offspring of suicide attempters with siblings concordant for suicidal behavior
Peripubertal suicide attempts in offspring of suicide attempters with siblings concordant for suicidal behavior
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DOI：
10.1176/appi.ajp.160.8.1486
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发表时间：
2003-08-01
影响因子：
17.7
通讯作者：
Mann, JJ
中科院分区：
文献类型：
--
作者：
Brent, DA;Oquendo, M;Mann, JJ
目的：作者试图确定1）自杀行为的家庭传播风险是否随着自杀企图的家庭负荷增加而增加，以及2）自杀行为的传播是否由冲动性攻击介导。方法：一项高风险研究的再分析比较了三个情绪障碍先证者组的后代：兄弟姐妹也企图自杀的自杀者（N=19），兄弟姐妹从未自杀企图的自杀者（N=73），以及兄弟姐妹也从未从事自杀行为的非自杀先证者（N=73）。先证者和后代进行了评估，就精神病理学，自杀企图的历史，冲动的侵略，并暴露于家庭advertisement.Results：后代的自杀未遂者与兄弟姐妹一致的自杀行为表现出较高的自杀企图的风险比非自杀先证者的后代，并有较早的自杀行为的发病年龄比后代的自杀未遂者与兄弟姐妹不一致的自杀行为。与其他两个先证者/后代组相比，来自自杀行为一致的兄弟姐妹对的先证者及其后代报告了更大的终身冲动性攻击。在后代中，冲动性攻击是最强大的预测早期年龄在第一次自杀attempt.Conclusions：自杀企图的家庭负荷可能会影响传输率以及自杀行为的发病年龄，其效果可能是介导的冲动性攻击的家庭传输。
Objective: The authors sought to determine 1) whether the risk for familial transmission of suicidal behavior is greater with increased family loading for suicide attempts, and 2) whether the transmission of suicidal behavior is mediated by impulsive aggression.Method: A reanalysis of a high-risk study compared the offspring of three mood disorder proband groups: suicide attempters with a sibling who also attempted suicide (N=19), suicide attempters whose siblings never made a suicide attempt (N=73), and nonsuicidal probands whose siblings also never engaged in suicidal behavior (N=73). Probands and offspring were assessed with respect to psychopathology, suicide attempt history, impulsive aggression, and exposure to familial adversity.Results: Offspring of suicide attempters with siblings concordant for suicidal behavior showed a higher risk of suicide attempt than did offspring of nonsuicidal probands and had an earlier age at onset of suicidal behavior than offspring of suicide attempters with siblings discordant for suicidal behavior. Probands from sibling pairs concordant for suicidal behavior and their offspring reported greater lifetime impulsive aggression compared with each of the other two proband/offspring groups. In the offspring, impulsive aggression was the most powerful predictor of early age at first suicide attempt.Conclusions: Familial loading for suicide attempts may affect rates of transmission as well as age at onset of suicidal behavior, and its effect may be mediated by the familial transmission of impulsive aggression.