The convergence of regenerative medicine and rehabilitation: federal perspectives.
The convergence of regenerative medicine and rehabilitation: federal perspectives.
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DOI：
10.1038/s41536-018-0056-1
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发表时间：
2018
影响因子：
7.2
通讯作者：
Yamaguchi D
中科院分区：
文献类型：
--
作者：
Rose LF;Wolf EJ;Brindle T;Cernich A;Dean WK;Dearth CL;Grimm M;Kusiak A;Nitkin R;Potter K;Randolph BJ;Wang F;Yamaguchi D
再生康复是再生医学和康复领域的原则和方法的协同整合，其目标是优化形式和功能以及患者的独立性。用于修复或替换受损组织或整个器官的再生医学方法不同于利用细胞（例如，干细胞），生物制剂（例如，生长因子）、使用生物材料和支架的方法、这些的任何组合。虽然再生医学提供了巨大的临床前景，再生康复提供了机会，通过纳入康复科学的原则，积极影响再生医学。再生医学本身可能不足以确保成功地转化为改善那些最需要的人的功能。相反，随着对再生医学原理的更好理解，康复研究人员可以更好地定制康复工作，以适应和最大限度地发挥再生方法的潜力。再生康复策略可以包括活动介导的可塑性，运动剂量，电刺激和营养增强剂。如果临床前研究不考虑通常属于康复研究领域的结果，如功能，运动范围，感觉和疼痛，那么将再生医学技术转化为人类的关键障碍可能难以克服。作者认为，鼓励来自多个学科的临床医生和研究人员合作和协同工作，将最大限度地恢复残疾和/或受伤患者的功能和生活质量，包括美国退伍军人和军人。联邦政府机构一直在投资研究和临床护理工作，重点是再生医学（NIH、NSF、VA和DoD）、康复科学（VA、NIH、NSF、DoD）以及最近的再生康复（NIH和VA）。随着科学的进步和技术的成熟，研究人员需要考虑再生康复的综合方法，以最大限度地提高结果，完全恢复患者的功能。
Regenerative rehabilitation is the synergistic integration of principles and approaches from the regenerative medicine and rehabilitation fields, with the goal of optimizing form and function as well as patient independence. Regenerative medicine approaches for repairing or replacing damaged tissue or whole organs vary from utilizing cells (e.g., stem cells), to biologics (e.g., growth factors), to approaches using biomaterials and scaffolds, to any combination of these. While regenerative medicine offers tremendous clinical promise, regenerative rehabilitation offers the opportunity to positively influence regenerative medicine by inclusion of principles from rehabilitation sciences. Regenerative medicine by itself may not be sufficient to ensure successful translation into improving the function of those in the most need. Conversely, with a better understanding of regenerative medicine principals, rehabilitation researchers can better tailor rehabilitation efforts to accommodate and maximize the potential of regenerative approaches. Regenerative rehabilitative strategies can include activity-mediated plasticity, exercise dosing, electrical stimulation, and nutritional enhancers. Critical barriers in translating regenerative medicine techniques into humans may be difficult to overcome if preclinical studies do not consider outcomes that typically fall in the rehabilitation research domain, such as function, range of motion, sensation, and pain. The authors believe that encouraging clinicians and researchers from multiple disciplines to work collaboratively and synergistically will maximize restoration of function and quality of life for disabled and/or injured patients, including U.S. Veterans and Military Service Members (MSMs). Federal Government agencies have been investing in research and clinical care efforts focused on regenerative medicine (NIH, NSF, VA, and DoD), rehabilitation sciences (VA, NIH, NSF, DoD) and, more recently, regenerative rehabilitation (NIH and VA). As science advances and technology matures, researchers need to consider the integrative approach of regenerative rehabilitation to maximize the outcome to fully restore the function of patients.
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影响因子：
15.9
作者：
Lu, Paul;Ceto, Steven;Tuszynski, Mark H.
通讯作者：
Tuszynski, Mark H.
DOI：
10.1097/ta.0b013e3182095b52
发表时间：
2011-05-01
影响因子：
--
作者：
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通讯作者：
Coimbra, Raul
影响因子：
3.4
作者：
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通讯作者：
Schmalbach, Cecelia
影响因子：
3.6
作者：
Janis, Jeffrey E.;Kwon, Robert K.;Attinger, Christopher E.
通讯作者：
Attinger, Christopher E.
影响因子：
8.3
作者：
Moniche, Francisco;Gonzalez, Alejandro;Gil-Peralta, Alberto
通讯作者：
Gil-Peralta, Alberto