Drying methods for protein pharmaceuticals.
Drying methods for protein pharmaceuticals.
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DOI：
10.1016/j.ddtec.2008.11.001
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
van de Weert, Marco
中科院分区：
文献类型：
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作者：
Maltesen, Morten Jonas;van de Weert, Marco
除去水是延长蛋白质制剂储存稳定性的常用方法。传统上，冷冻干燥一直是选择的方法，但喷雾干燥和超临界干燥在过去十年中获得了越来越多的兴趣。干燥技术的正确选择对最终药物产品和工艺的整体经济性具有重大影响。
Removal of water is a common method to prolong the storage stability of protein formulations. Traditionally, freeze-drying has been the method of choice, but spray drying and supercritical drying have gained increased interest in the past decade. The proper choice of drying technology has a significant impact on the final pharmaceutical product and on the overall economy of the process.: