Non-invasive ventilation reduces respiratory tract infections in children with neuromuscular disorders
Non-invasive ventilation reduces respiratory tract infections in children with neuromuscular disorders
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DOI：
10.1002/ppul.20740
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发表时间：
2008-01-01
影响因子：
3.1
通讯作者：
Mellies, U.
中科院分区：
文献类型：
--
作者：
Dohna-Schwake, C.;Podlewski, P.;Mellies, U.
无创通气（NIV）已被证明可以改善慢性神经肌肉疾病患者的气体交换和生存率。关于它对呼吸道感染（RTI）的影响知之甚少。24例经常使用NIV的患者和11例未使用NIV的神经肌肉疾病患者回答了一份关于使用NIV和辅助咳嗽技术、流感和肺炎球菌疫苗接种状况以及RTI频率和严重程度的问卷。此外，我们对12例至少5年接受通气的患者进行了回顾性病历审查。在NIV的第一年，全科医生因RTI的咨询从每年9.2 +/- 20.8下降到3.2 +/- 5.3（P < 0.005），因RTI而接受抗生素治疗的次数从每年4.1 +/- 3.4次降至1.9 +/- 2.2次（P < 0.005），因呼吸道感染而住院的人数从每年1.6 ± 1.7例下降到0.7 ± 1.3例（P
Non-invasive ventilation (NIV) has been shown to improve gas exchange and survival in patients with chronic neuromuscular disorders. Little is known about its influence on respiratory tract infections (RTIs). Twenty-four patients with regular use of NIV and 11 patients without NIV with neuromuscular disorders answered a questionnaire concerning the use of NIV and assisted coughing techniques, the status of influenza and pneumococcus vaccination, and the frequency and severity of RTIs. Additionally, we performed a retrospective chart review of twelve patients who were ventilated over a period of at least 5 years. In the first year of NIV consultations of a general practitioner due to RTI decreased from 9.2 +/- 20.8 to 3.2 +/- 5.3 per year (P < 0.005), the number of antibiotic treatment due to RTI decreased from 4.1 +/- 3.4 to 1.9 +/- 2.2 per year (P < 0.005) and the number of hospital admissions due to RTI decreased from 1.6 +/- 1.7 to 0.7 +/- 1.3 per year (P