Bisleuconothines B-D, Modified Eburnane-Aspidosperma Bisindole Alkaloids from Leuconotis griffithii
Bisleuconothines B-D, Modified Eburnane-Aspidosperma Bisindole Alkaloids from Leuconotis griffithii
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DOI：
10.1021/acs.jnatprod.8b00749
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发表时间：
2018-11-01
影响因子：
5.1
通讯作者：
Morita, Hiroshi
中科院分区：
文献类型：
--
作者：
Nugroho, Alfarius Eko;Zhang, Wenjia;Morita, Hiroshi
从灰白蜡树树皮中分离得到3个新的双吲哚生物碱，分别为双亮油酸B-D(1-3)。通过一维和二维核磁共振波谱和密度泛函理论计算确定了它们的结构。双亮氨酸B(1)是第一个连接C-16-C-10‘和C-2-O-C-9’的单萜吲哚生物碱二聚体。当对A549人肺腺癌细胞进行测试时，所有化合物都被认为是无细胞毒性的(IC50和GT；10MU)。
Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10' and C-2-O-C-9'. All compounds were deemed noncytotoxic (IC50 > 10 mu M) when tested against A549 human lung adenocarcinoma cells.