Comparison of Diagnostic Value of I-123 MIBG and High-Dose I-131 MIBG Scintigraphy Including Incremental Value of SPECT/CT Over Planar Image in Patients With Malignant Pheochromocytoma/Paraganglioma and Neuroblastoma
Comparison of Diagnostic Value of I-123 MIBG and High-Dose I-131 MIBG Scintigraphy Including Incremental Value of SPECT/CT Over Planar Image in Patients With Malignant Pheochromocytoma/Paraganglioma and Neuroblastoma
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DOI：
10.1097/rlu.0b013e3181feeb5e
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发表时间：
2011-01-01
影响因子：
10.6
通讯作者：
Kinuya, Seigo
中科院分区：
文献类型：
--
作者：
Fukuoka, Makoto;Taki, Junichi;Kinuya, Seigo
目的：比较I-123 MIBG放射性成像与高剂量I-131 MIBG的病变可检测性，并评价SPECT/CT相对于平面成像在I-131 MIBG治疗恶性嗜铬细胞瘤/副神经节瘤和神经母细胞瘤患者中病变检测和定位方面的增量效益。材料和方法：我们回顾性研究了16例恶性嗜铬细胞瘤/副神经节瘤和神经母细胞瘤患者，他们被转诊接受I-131 MIBG治疗。我们研究了同一患者在2周内获得的10对I-123和高剂量I-131 MIBG研究中的病变可检测性。在16例患者的31项I-123 MIBG血管造影研究和12例患者的17项高剂量I-131 MIBG血管造影研究中，我们比较了平面和SPECT/CT图像的病变可检测性和定位。I-123 MIBG平面成像和SPECT/CT以及高剂量I-131 MIBG平面成像和SPECT/CT检测到的病变数量分别为3.0和3.7，7.3和7.7，分别在I-123 MIBG脑血管造影的12例患者（75%）中的25项研究（81%）和高剂量I-131 MIBG脑血管造影的9例患者（75%）中的9项研究（53%）中，SPECT/CT图像比平面图像提供了额外的诊断信息。即使与I-123 MIBG SPECT/CT图像和高剂量I-131 MIBG造影相比，治疗后高剂量I-131 MIBG造影在病变可检测性方面也上级I-123 MIBG造影。131例恶性神经内分泌肿瘤患者的MIBG平面图像。与平面图像相比，SPECT/CT图像有助于准确识别解剖定位。
Purpose: To compare lesion detectability of I-123 MIBG scintigraphy with that of high-dose I-131 MIBG and to evaluate incremental benefit of SPECT/CT over planar image for the detection and localization of the lesions in patients with I-131 MIBG therapy for malignant pheochromocytoma/paraganglioma and neuroblastoma.Materials and Methods: We retrospectively investigated 16 patients with malignant pheochromocytoma/paraganglioma and neuroblastoma, who were referred for I-131 MIBG therapy. We investigated the lesion detectability in 10 pairs of I-123 and high-dose I-131 MIBG studies of the same patient, obtained within 2 weeks. In 31 studies of I-123 MIBG scintigraphy in 16 patients and 17 studies of high-dose I-131 MIBG scintigraphy in 12 patients, we compared planar and SPECT/CT images for the lesion detectability and localization.Results: The number of lesions detected by I-123 MIBG planer image and SPECT/CT and high-dose planer I-131 MIBG and SPECT/CT were 3.0 and 3.7, 7.3 and 7.7 per study, respectively. SPECT/CT images provided additional diagnostic information over planar images in 25 studies (81%) of 12 patients (75%) in I-123 MIBG scintigraphy and in 9 studies (53%) of 9 patients (75%) in high-dose I-131 MIBG scintigraphy.Conclusion: Post-therapy high-dose I-131 MIBG scintigraphy is superior to I-123 MIBG scintigraphy in lesion detectability even in comparison with I-123 MIBG SPECT/CT images and high-dose I-131 MIBG planar images in patients with malignant neuroendocrine tumors. SPECT/CT images are helpful for accurate identification of anatomic localization compared with planar images.