Pyrazinoic Acid Decreases the Proton Motive Force, Respiratory ATP Synthesis Activity, and Cellular ATP Levels
Pyrazinoic Acid Decreases the Proton Motive Force, Respiratory ATP Synthesis Activity, and Cellular ATP Levels
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DOI：
10.1128/aac.00507-11
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发表时间：
2011-11-01
影响因子：
4.9
通讯作者：
Bald, Dirk
中科院分区：
文献类型：
--
作者：
Lu, Ping;Haagsma, Anna C.;Bald, Dirk
一线抗结核药物吡津酰胺的活性形式吡津酸在亚细胞分枝杆菌膜分析中降低了质子动力和呼吸ATP合成速率。吡嗪酸还显著降低了牛分枝杆菌卡介苗细胞内的ATP水平。这些结果表明，该药物的主要杀伤机制可能是通过耗尽细胞内的ATP储备来发挥作用。
Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results indicate that the predominant mechanism of killing by this drug may operate by depletion of cellular ATP reserves.