Stem cell sprays for neurological injuries: a perspective.
Stem cell sprays for neurological injuries: a perspective.
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干细胞喷雾治疗神经损伤：一个视角。
DOI：
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发表时间：
2021
影响因子：
3.8
通讯作者：
Divya Maitreyi Chari
中科院分区：
文献类型：
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作者：
W. Woods;Daisy Evans;Aina Mogas Barcons;N. Tzerakis;C. Adams;Divya Maitreyi Chari
脑和脊髓损伤具有严重的临床后果，医疗保健系统的成本很高。神经细胞移植疗法具有显著的转化潜力，以促进损伤后再生，临床试验开始用于各种病理。然而，在再生应用中，存在与用于将移植细胞全身或直接递送至神经组织的当前临床方法相关的挑战。这些风险包括与神经组织中的手术显微注射（例如出血、细胞凝集）相关的风险，以及由于全身清除或细胞通过细针进入密集神经组织导致的高细胞损失。本文提出了支持细胞喷雾递送技术与当前细胞递送方法相比可以为神经移植治疗提供显着转化益处的概念的证据。潜在的好处包括快速/同质细胞递送、大表面积释放、侵入性最小、与急性损伤中的神经外科手术兼容、没有可预测的临床并发症以及将细胞疗法与药物/生物分子递送联合收割机结合起来的能力。因此，我们认为细胞喷雾递送技术的发展代表了开发用于再生神经学的先进细胞疗法的关键目标。
Injuries to the brain and spinal cord have major clinical consequences with high costs for healthcare systems. Neural cell transplantation therapies have significant translational potential to promote regeneration post-injury with clinical trials commencing for various pathologies. However, there are challenges associated with current clinical approaches used for systemic or direct delivery of transplant cells to neural tissue in regenerative applications. These include risks associated with surgical microinjection into neural tissue (e.g. haemorrhage, cell clumping) and high cell loss due to systemic clearance or with cell passage through fine gauge needles into densely packed neural tissue. This article presents lines of evidence supporting the concept that cell spray delivery technology can offer significant translational benefits for neural transplantation therapy, versus current cell delivery methods. Potential benefits include rapid/homogenous cell delivery, release over large surface areas, minimal invasiveness, compatibility with neurosurgical procedures in acute injury, no predictable clinical complications and the capacity to combine cell therapies with drug/biomolecule delivery. Accordingly, we consider that the development of cell spray delivery technology represents a key goal to develop advanced cell therapies for regenerative neurology.
影响因子：
4.2
作者：
Bramlett, Helen M.;Dietrich, W. Dalton
通讯作者：
Dietrich, W. Dalton
影响因子：
4
作者：
Fischer, Uwe M.;Harting, Matthew T.;Cox, Charles S., Jr.
通讯作者：
Cox, Charles S., Jr.