Elastomeric surgical sealant for hemostasis of cardiovascular anastomosis under full heparinization
Elastomeric surgical sealant for hemostasis of cardiovascular anastomosis under full heparinization
复制标题
DOI：
10.1016/j.ejcts.2007.06.046
复制
发表时间：
2007-11-01
影响因子：
3.4
通讯作者：
Matsuda, Takehisa
中科院分区：
文献类型：
--
作者：
Eto, Masataka;Morita, Shigeki;Matsuda, Takehisa
目的：我们开发了一种新型手术密封剂，一种粘性二异氰酸酯预聚物，适用于动脉止血。本研究的目的是评估这种手术密封剂在肝素化条件下的止血效果。方法：应用犬颈动脉端端吻合术验证该密封剂的有效性。使用了五只杂种狗。完全肝素化后，夹住、分开颈动脉，并用四道简单的间断缝合线进行端端吻合。将密封剂涂在吻合处。 5分钟后移除夹子并评估止血效果。三只狗立即接受宏观评估。两只狗分别在3个月和16个月后接受血管造影。结果：移除夹子后，任何吻合处均未立即发生出血。宏观观察显示密封剂没有渗漏到管腔中。颈动脉造影显示吻合良好，无狭窄。结论：一种新型手术封闭剂在完全肝素化的情况下对湿润组织表现出快速有效的止血作用。 (C) 2007 年欧洲心胸外科协会。由 Elsevier B.V. 出版。保留所有权利。
Purpose: We developed a novel surgical sealant, a viscous diisocyanated prepolymer, applicable to arterial hemostasis. The purpose of this study is to evaluate hemostatic effect of this surgical sealant under heparinized conditions. Methods: The effectiveness of this sealant was verified by applying it to the end-to-end anastomosis of canine carotid arteries. Five mongrel dogs were used. After a complete heparinization, the carotid arteries were clamped, divided, and end-to-end anastomoses were performed with four simple interrupted sutures. The sealant was coated on the anastomosis. After 5 min the clamps were removed and the hemostatic effect was evaluated. Three dogs were immediately subjected to macroscopic evaluation. Two dogs were subjected to angiography after 3 months and 16 months, respectively. Results: No bleeding occurred in any of the anastomoses immediately after the removal of the clamp. Macroscopic finding revealed no leakage of the sealant into the lumen. Carotid angiography revealed patent anastomoses without stenosis. Conclusion: A novel surgical sealant exhibited rapid and potent hemostatic effect on a moisturized tissue under full heparinization. (C) 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.