Insulin-like growth factor I stimulates growth in hypophysectomized rats
Insulin-like growth factor I stimulates growth in hypophysectomized rats
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DOI：
10.1038/296252a0
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发表时间：
1982-03
期刊：
影响因子：
64.8
通讯作者：
E. Schoenle;J. Zapf;R. Humbel;E. Froesch
中科院分区：
文献类型：
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作者：
E. Schoenle;J. Zapf;R. Humbel;E. Froesch
虽然生长激素会刺激垂体切除大鼠的生长，但长期以来人们提出1,2这种作用不是直接的，而是由生长调节素肽介导的。其中两个是胰岛素样生长因子 I (IGF I) 和胰岛素样生长因子 II (IGF II)3，之所以如此命名是因为它们在结构上与胰岛素密切相关4,5。 IGF I 和 IGF II 在体外具有生长调节素活性6,7，但迄今为止，还没有足够的肽来测试它们的体内活性。我们现在报道纯 IGF I 以剂量依赖性方式刺激垂体切除大鼠的生长。这有力地支持了生长激素的作用是由生长调节素家族的肽介导的观点。
Although growth hormone stimulates the growth of hypophysectomized rats, it has long been proposed1,2that the effects are not direct but instead are mediated by the somatomedin peptides. Two of these are insulin-like growth factor I (IGF I) and insulin-like growth factor II (IGF II)3, so called because they are closely related to insulin in structure4,5. IGF I and IGF II have somatomedin activityin vitro6,7but until now insufficient amounts of the peptides have been available to test theirin vivoactivity. We now report that pure IGF I stimulates the growth of hypophysectomized rats in a dose-dependent manner. This strongly supports the notion that the action of growth hormone is mediated by peptides of the somatomedin family.