Plasma β-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy
Plasma β-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy
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DOI：
10.1212/01.wnl.0000191403.95453.6a
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发表时间：
2006-01-10
期刊：
影响因子：
9.9
通讯作者：
Greenberg, SM
中科院分区：
文献类型：
--
作者：
Gurol, ME;Irizarry, MC;Greenberg, SM
背景：微血管脑损伤通常通过 MRI 上白质高信号 (WMH) 的程度来衡量，是导致老年人认知障碍的重要因素。最近的研究表明循环β-淀粉样肽在微血管功能障碍和白质疾病中发挥作用。方法：作者对 54 名阿尔茨海默病 (AD) 或轻度认知障碍 (AD/MCI) 受试者以及由 42 名脑淀粉样血管病 (CAA) 受试者组成的独立组进行了与 WMH 相关的临床、生化和遗传因素的横断面研究。 WMH 的范围通过计算机辅助体积测量标准化为颅内大小 (nWMH) 来确定。生化测量包括通过特定酶联免疫吸附测定检测的 40 和 42 氨基酸种类的 β-淀粉样蛋白（A β 40 和 A β 42）的血浆浓度。结果：两组中血浆 A β 40 浓度均与 nWMH 相关（AD/MCI 中相关系数 = 0.48，CAA 中相关系数 = 0.42，p
Background: Microvascular brain injury, typically measured by extent of white matter hyperintensity (WMH) on MRI, is an important contributor to cognitive impairment in the elderly. Recent studies suggest a role for circulating beta-amyloid peptide in microvascular dysfunction and white matter disease. Methods: The authors performed a cross-sectional study of clinical, biochemical, and genetic factors associated with WMH in 54 subjects with Alzheimer disease (AD) or mild cognitive impairment (AD/MCI) and an independent group of 42 subjects with cerebral amyloid angiopathy (CAA). Extent of WMH was determined by computer-assisted volumetric measurement normalized to intracranial size (nWMH). Biochemical measurements included plasma concentrations of the 40- and 42-amino acid species of beta-amyloid (A beta 40 and A beta 42) detected by specific enzyme-linked immunosorbent assays. Results: Plasma A beta 40 concentrations were associated with nWMH in both groups (correlation coefficient = 0.48 in AD/MCI, 0.42 in CAA, p