Transcription-driven DNA supercoiling and gene expression control
Transcription-driven DNA supercoiling and gene expression control
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DOI：
10.2741/968
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Wu, HY
中科院分区：
文献类型：
--
作者：
Chen, CC;Wu, HY
DNA超螺旋在基因表达调控中起着重要作用，但DNA超螺旋调控基因表达的机制尚不清楚。转录过程本身产生DNA超螺旋的事实使问题进一步复杂化。转录驱动的DNA超螺旋是局部和短暂的。这种DNA超螺旋效应可能在控制复杂的基因表达调控中发挥重要作用。以鼠伤寒沙门氏菌topA突变体中leu-500突变的抑制为模型系统，我们提出了转录驱动的DNA超螺旋对基因表达控制的影响的观点。
DNA supercoiling plays important roles in gene expression regulation, although, the underlying mechanisms whereby DNA supercoiling modulates gene expression remain elusive. The fact that the transcription process itself generates DNA supercoiling has further complicated the issue. Transcription-driven DNA supercoiling is local and transient. Such a DNA supercoiling effect is likely to play important roles in controlling complex gene expression regulation. Using the suppression of the leu-500 mutation in Salmonella typhimurium topA mutants as a model system, we put forward our view of the effects of transcription-driven DNA supercoiling on gene expression control.