Caffeine augmentation of electroconvulsive seizures.
Caffeine augmentation of electroconvulsive seizures.
复制标题
咖啡因增强电惊厥发作。
DOI：
10.1007/bf02245072
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发表时间：
1994
影响因子：
3.4
通讯作者：
Fochtmann,L
中科院分区：
文献类型：
--
作者：
Francis,A;Fochtmann,L
咖啡因在临床上已被用于延长电惊厥治疗（ECT）中癫痫发作的时间。本研究旨在建立咖啡因增强癫痫发作的动物模型，以进一步研究药物控制癫痫发作长度的机制和效果。在对大鼠进行电惊厥刺激（ECS）之前，增加咖啡因剂量（0-200 mg/kg，IP），并通过经典强直阵挛性惊厥运动的时间来量化由此产生的癫痫发作长度。在这种模式下，咖啡因导致癫痫发作持续时间呈剂量依赖性增加。咖啡因的这种促惊厥作用在给药后 1 分钟内即可检测到，持续至少 230 分钟，并且是可逆的。结果表明，癫痫发作长度是电惊厥癫痫发作的药理学修正的可行措施。他们还建议可以在动物身上有效地建立药理学改良的 ECS 模型。
Caffeine has been used clinically to increase seizure length in electroconvulsive treatment (ECT). The present study was designed to establish an animal model of caffeine-augmented seizures for further study of mechanisms and effects of pharmacological manipulation of seizure length. Increasing doses of caffeine (0–200 mg/kg, IP) were given before electroconvulsive stimulation (ECS) in rats and resulting seizure lengths were quantified by timing of classical tonic-clonic convulsive movements. With this paradigm, caffeine led to a dose-dependent increase in seizure duration. This proconvulsant action of caffeine was detectable within 1 min after dosing, persisted for at least 230 min and was reversible. The results suggest that seizure length is a practicable measure in pharmacological modification of electroconvulsive seizures. They also suggest that pharmacologically-modified ECS can be modeled effectively in animals.