Congenital anomalies in twins: a register-based study
Congenital anomalies in twins: a register-based study
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DOI：
10.1093/humrep/den104
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发表时间：
2008-06-01
影响因子：
6.1
通讯作者：
Wright, C.
中科院分区：
文献类型：
--
作者：
Glinianaia, S. V.;Rankin, J.;Wright, C.
背景：双胞胎先天性畸形的风险高于单胞胎，但与绒毛膜有关的报道较少。本研究的目的是通过绒毛膜和主要亚型描述双胎妊娠中先天性畸形的患病率，并与单胎妊娠的患病率进行比较。方法：研究人群包括2329双胎妊娠（4658双胞胎）和147655单胎分娩在英格兰东北部在1998年至2002年。数据来自基于人口的北方多胎妊娠登记和北方先天性异常调查。研究结果：双胞胎先天畸形率为405.8/10000，单胞胎为238.2/10000 [率比（RR）= 1.7，95%置信区间（CI）1.5-2.0]。在已知绒毛膜性的双胞胎中（占所有双胞胎的84.8%），单绒毛膜（MC）双胞胎的先天性畸形患病率（633.6/10000）几乎是双绒毛膜双胞胎（343.7/10000; RR = 1.8，95%CI 1.3-2.5）的两倍。与单胎妊娠相比，双胎妊娠的所有主要类型的畸形（染色体异常除外）的先天性畸形率均增加。结论：这项研究使用高质量的，基于人群的多胎妊娠和先天性畸形数据发现，双胞胎，特别是MC双胞胎，比单胞胎有更高的先天性畸形风险。
BACKGROUND: The risk of congenital anomalies in twins is higher than in singletons, but it is less well reported in relation to chorionicity. The aim of this study was to describe the prevalence of congenital anomalies in twin pregnancies by chorionicity and by major subtype and compare the rates with those in singletons. METHODS: The study population included 2329 twin pregnancies (4658 twins) and 147 655 singletons delivered in the Northeast of England during 1998-2002. Data were obtained from the population-based Northern Multiple Pregnancy Register and Northern Congenital Abnormality Survey. RESULTS: The rate of congenital anomalies in twins was 405.8 per 10 000 twins versus 238.2 per 10 000 singletons [rate ratios (RR) = 1.7, 95% confidence interval (CI) 1.5-2.0]. In twins with known chorionicity (84.8% of all twins), the prevalence of congenital anomalies in monochorionic (MC) twins (633.6 per 10 000) was nearly twice that in dichorionic (343.7 per 10 000; RR = 1.8, 95% CI 1.3-2.5). There was an increased rate of congenital anomalies in twin compared with singleton pregnancies for all major types of anomalies, except chromosomal abnormalities. CONCLUSIONS: This study using high quality, population-based data on multiple pregnancies and congenital anomalies found that twins, particularly MC twins, have a higher risk of congenital anomalies than singletons.