The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis.
The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis.
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DOI：
10.1016/j.cell.2009.06.031
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发表时间：
2009-08-21
期刊：
影响因子：
64.5
通讯作者：
Poethig RS
中科院分区：
文献类型：
--
作者：
Wu G;Park MY;Conway SR;Wang JW;Weigel D;Poethig RS
在植物中，从幼枝发育到成年阶段的过渡伴随着营养形态的变化和生殖潜力的增加。在这里，我们描述了这种转变的监管机制。我们表明，miR156是必要的和足够的青少年阶段的表达，并通过协调控制这一过程的不同方面的几个途径的表达，调节青少年到成人的过渡的时间。miR156通过抑制功能上不同的SPL转录因子的表达起作用。miR172在miR156的下游起作用以促进成体表皮身份。miR156通过SPL9调节miR172的表达，SPL9与SPL10冗余地直接促进miR172b的转录。因此，像秀丽隐杆线虫的幼虫到成虫的转变一样，拟南芥的幼虫到成虫的转变是由顺序操作的miRNA介导的。miR156和miR172受其靶向的转录因子的正调控，表明负反馈环有助于幼年期和成年期的稳定性。
The transition from the juvenile to the adult phase of shoot development in plants is accompanied by changes in vegetative morphology and an increase in reproductive potential. Here we describe the regulatory mechanism of this transition. We show that miR156 is necessary and sufficient for the expression of the juvenile phase, and regulates the timing of the juvenile-to-adult transition by coordinating the expression of several pathways that control different aspects of this process. miR156 acts by repressing the expression of functionally distinct SPL transcription factors. miR172 acts downstream of miR156 to promote adult epidermal identity. miR156 regulates the expression of miR172 via SPL9 which, redundantly with SPL10, directly promotes the transcription of miR172b. Thus, like the larval-to-adult transition in Caenorhabditis elegans, the juvenile-to-adult transition in Arabidopsis is mediated by sequentially operating miRNAs. miR156 and miR172 are positively regulated by the transcription factors they target, suggesting that negative feedback loops contribute to the stability of the juvenile and adult phases.
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