EFFICACY OF PHOTODYNAMIC THERAPY AGAINST DOXORUBICIN-RESISTANT MURINE TUMORS
EFFICACY OF PHOTODYNAMIC THERAPY AGAINST DOXORUBICIN-RESISTANT MURINE TUMORS
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DOI：
10.1016/0304-3835(95)03818-h
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发表时间：
1995-07-13
期刊：
影响因子：
9.7
通讯作者：
VALENTINI, G
中科院分区：
文献类型：
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作者：
CANTI, G;LATTUADA, D;VALENTINI, G
光动力疗法(PDT)是一种相对较新的癌症治疗方法，它利用光敏剂的光激发产生与细胞毒性氧相关的物质。在本研究中，我们探讨了光动力疗法是否对阿霉素耐药的小鼠肿瘤有治疗作用。我们比较了光动力疗法、二磺化铝络合物(Al(S)2PC)和激光对阿霉素敏感的小鼠肿瘤、B16黑色素瘤(B16)、L1210白血病(L1210)、P388淋巴瘤(P388)以及相应的阿霉素耐药株(B16/Dx、L1210/Dx和P388/Dx)的疗效。荷L1210-L1210iDx、P388-P388/Dx和B16-B16/Dx的小鼠分别给予ALS(2)Pc和激光(100 mW/cm(2)×10min)5 mg/kg或阿霉素(10 mg/kg或12 mg/kg)静脉注射。结果表明，PDT对所有肿瘤都有效，而阿霉素只对L1210、P388和B16这三个敏感肿瘤株有效。这些观察表明，光动力疗法可能是治疗耐药肿瘤的一种有益的替代疗法。
Photodynamic therapy (PDT) is a relatively new cancer treatment modality that employs light excitation of a photosensitizer to yield cytotoxic oxygen-related species. In the present study we explored whether PDT would have therapeutic effect against doxorubicin-resistant murine tumors. We compared the efficacy of PDT with aluminium disulphonated phthalocyanine (Al(S)2Pc) and laser light on the doxorubicin-sensitive murine tumors, B16 melanoma (B16), L1210 leukemia (L1210), P388 lymphoma (P388) and the corresponding doxorubicin-resistant lines (B16/Dx, L1210/Dx and P388/Dx). Mice bearing L1210-L1210iDx, P388-P388/Dx and B16-B16/Dx, were treated with 5 mg/kg of AlS(2)Pc and laser light (100 mW/cm(2) x 10 min of exposure) or with doxorubicin (10 or 12 mg/kg i.v.). The results show that PDT is active versus all tumors while doxorubicin is effective only against the three sensitive tumor lines (L1210, P388 and B16). These observations suggest that PDT might be a beneficial alternative treatment for drug-resistant tumors.