Genetics of diabetic nephropathy in the Pima Indians.
Genetics of diabetic nephropathy in the Pima Indians.
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DOI：
10.1007/s11892-001-0046-2
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发表时间：
2001-12-01
影响因子：
4.2
通讯作者：
Hanson, R L
中科院分区：
文献类型：
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作者：
Imperatore, G;Knowler, W C;Hanson, R L
糖尿病肾病是工业化国家肾衰竭的主要原因。糖尿病肾病是一种常见的慢性病。在皮马印第安人以及其他人群中的研究表明，糖尿病肾病在家庭中聚集。家族聚集性反映了一个主要基因的影响的假设，正式测试分离分析的糖尿病肾病在皮马印第安人2型糖尿病。分离分析提供了强有力的证据，一个主要的遗传效应对糖尿病肾病的患病率，这表明，糖尿病肾病的一些遗传决定因素可能有足够大的影响，通过连锁分析检测。因此，我们分析了全基因组扫描的数据，以确定糖尿病皮马印第安人肾病的易感位点。通过参数（基于模型）和非参数方法进行的分析揭示了染色体3q、7q、18q和20p上肾病易感基因座的初步证据。
Diabetic nephropathy is the leading cause of renal failure in industrialized countries. There is strong evidence that diabetic nephropathy is influenced by genetic factors. Studies in the Pima Indians as well as in other populations demonstrate that diabetic nephropathy aggregates in families. The hypothesis that the familial aggregation reflects the effect of a major gene was formally tested by segregation analysis of diabetic nephropathy in Pima Indians with type 2 diabetes. The segregation analysis provided strong evidence for a major genetic effect on the prevalence of diabetic nephropathy; this suggests that some of the genetic determinants of diabetic nephropathy may have effects of sufficient magnitude to be detected by linkage analysis. Therefore, we analyzed data from a genome-wide scan to identify susceptibility loci for nephropathy in diabetic Pima Indians. Analyses conducted by both parametric (model-based) and nonparametric methods revealed tentative evidence for nephropathy susceptibility loci on chromosomes 3q, 7q, 18q, and 20p.